Gene
crp3
- ID
- ZDB-GENE-060503-220
- Name
- C-reactive protein 3
- Symbol
- crp3 Nomenclature History
- Previous Names
-
- PTX3 (1)
- si:ch211-234p6.12
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within defense response to virus. Predicted to be located in extracellular region. Is expressed in digestive system; fin; gill; immune system; and muscle. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein) and APCS (amyloid P component, serum).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Pentaxin, conserved site | Pentraxin domain-containing protein | Pentraxin-related |
|---|---|---|---|---|---|---|
| UniProtKB:A8KBB1 | InterPro | 223 | ||||
| UniProtKB:A3KPG5 | InterPro | 223 | ||||
| UniProtKB:A0AB32TJM2 | InterPro | 436 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-234P6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171906 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171909 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114915 (1) | 801 nt | ||
| Genomic | GenBank:BX001030 (1) | 155645 nt | ||
| Polypeptide | UniProtKB:A0AB32TJM2 (1) | 436 aa |
No data available
- Saralahti, A.K., Harjula, S.E., Rantapero, T., Uusi-Mäkelä, M.I.E., Kaasinen, M., Junno, M., Piippo, H., Nykter, M., Lohi, O., Rounioja, S., Parikka, M., Rämet, M. (2023) Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genetics. 19:e1010586e1010586
- Bello-Perez, M., Falco, A., Novoa, B., Perez, L., Coll, J. (2019) Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms. PLoS One. 14:e0201509
- M, R., Medina-Gali, ., Belló-Pérez, M., Martínez-López, A., Falcó, A., Ortega-Villaizan, M.M., Encinar, J.A., Novoa, B., Coll, J., Perez, L. (2018) Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. Fish & shellfish immunology. 82:514-521
- Bello-Perez, M., Falco, A., Medina-Gali, R., Pereiro, P., Encinar, J.A., Novoa, B., Perez, L., Coll, J. (2017) Neutralization of viral infectivity by zebrafish c-reactive protein isoforms. Molecular immunology. 91:145-155
- Yilmaz, O., Patinote, A., Nguyen, T.V., Com, E., Lavigne, R., Pineau, C., Sullivan, C.V., Bobe, J. (2017) Scrambled eggs: Proteomic portraits and novel biomarkers of egg quality in zebrafish (Danio rerio). PLoS One. 12:e0188084
- Chen, R., Qi, J., Yuan, H., Wu, Y., Hu, W., Xia, C. (2015) Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces. Journal of structural biology. 189(3):259-68
- Estepa, A., Coll, J. (2015) Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype. PLoS One. 10:e0135483
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Falco, A., Cartwright, J.R., Wiegertjes, G.F., and Hoole, D. (2012) Molecular characterization and expression analysis of two new C-reactive protein genes from common carp (Cyprinus carpio). Developmental and comparative immunology. 37(1):127-138
- Gonçalves, A.F., Páscoa, I., Neves, J.V., Coimbra, J., Vijayan, M.M., Rodrigues, P., and Wilson, J.M. (2012) The inhibitory effect of environmental ammonia on Danio rerio LPS induced acute phase response. Developmental and comparative immunology. 36(2):279-88
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