Gene

alg2

ID
ZDB-GENE-060502-2
Name
ALG2 alpha-1,3/1,6-mannosyltransferase
Symbol
alg2 Nomenclature History
Previous Names
  • im:7145131
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have alpha-1,3-mannosyltransferase activity and glycolipid mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein glycosylation in endoplasmic reticulum. Localizes to nucleus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from DeRossi et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With alg2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital disorder of glycosylation Ii Alliance Congenital disorder of glycosylation, type Ii 607906
congenital myasthenic syndrome 14 Alliance Myasthenic syndrome, congenital, 14, with tubular aggregates 616228
Associated With alg2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001296 Glycosyl transferase, family 1
Domain IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain
Family IPR027054 Mannosyltransferase ALG2
Domain Details Per Protein
Protein Length Glycosyl transferase, family 1 Glycosyltransferase subfamily 4-like, N-terminal domain Mannosyltransferase ALG2
UniProtKB:A7MBR9 402
UniProtKB:F1QVV7 242
UniProtKB:Q7ZU66 422
UniProtKB:F1QPS1 455
UniProtKB:A7MCL4 402
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations