Gene
kalrnb
- ID
- ZDB-GENE-060421-7244
- Name
- kalirin RhoGEF kinase b
- Symbol
- kalrnb Nomenclature History
- Previous Names
-
- wu:fc60a10
- zgc:136817
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within hemopoiesis. Predicted to be active in cytoplasm and postsynaptic density. Predicted to be extrinsic component of membrane. Is expressed in EVL. Orthologous to human KALRN (kalirin RhoGEF kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Hong et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Bielczyk-Maczyńska et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR028570 | Kalirin/Triple functional domain protein, SH3 domain 1 |
| Domain | IPR047054 | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 |
| Family | IPR051336 | Rho GTPase-activating Guanine Nucleotide Exchange Factors |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
| Repeat | IPR002017 | Spectrin repeat |
| Repeat | IPR018159 | Spectrin/alpha-actinin |
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 | Kalirin/Triple functional domain protein, SH3 domain 1 | PH-like domain superfamily | Pleckstrin homology domain | Rho GTPase-activating Guanine Nucleotide Exchange Factors | SH3 domain | SH3-like domain superfamily | Spectrin/alpha-actinin | Spectrin repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZL0
|
686 | |||||||||||||
|
UniProtKB:Q1RLV0
|
471 | |||||||||||||
|
UniProtKB:A0A2R8RHL8
|
2306 | |||||||||||||
|
UniProtKB:A0A0R4IJ99
|
616 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kalrnb-201
(1)
|
Ensembl | 2,926 nt | ||
| mRNA |
kalrnb-202
(1)
|
Ensembl | 751 nt | ||
| mRNA |
kalrnb-203
(1)
|
Ensembl | 3,123 nt | ||
| mRNA |
kalrnb-204
(1)
|
Ensembl | 7,965 nt | ||
| mRNA |
kalrnb-205
(1)
|
Ensembl | 8,639 nt |
Interactions and Pathways
No data available
Plasmids
No data available