Gene

kalrnb

ID

ZDB-GENE-060421-7244

Name

kalirin RhoGEF kinase b

Symbol

kalrnb Nomenclature History

Previous Names

wu:fc60a10
zgc:136817

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Involved in hemopoiesis. Is expressed in EVL. Orthologous to human KALRN (kalirin RhoGEF kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Hong et al., 2010

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Bielczyk-Maczyńska et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kalrnb Human Ortholog

No data available

Associated With kalrnb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR028570	Kalirin/Triple functional domain protein, SH3 domain 1
Domain	IPR047054	Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1
Family	IPR051336	Rho GTPase-activating Guanine Nucleotide Exchange Factors
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036865	CRAL-TRIO lipid binding domain superfamily
Repeat	IPR002017	Spectrin repeat
Repeat	IPR018159	Spectrin/alpha-actinin

Domain Details Per Protein

Protein	Length	CRAL-TRIO lipid binding domain	CRAL-TRIO lipid binding domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1	Kalirin/Triple functional domain protein, SH3 domain 1	PH-like domain superfamily	Pleckstrin homology domain	Rho GTPase-activating Guanine Nucleotide Exchange Factors	SH3 domain	SH3-like domain superfamily	Spectrin/alpha-actinin	Spectrin repeat
UniProtKB:A0A8M6YZL0 InterPro	686
UniProtKB:Q1RLV0 InterPro	471
UniProtKB:A0A2R8RHL8 InterPro	2306
UniProtKB:A0A0R4IJ99 InterPro	616

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kalrnb-201 (1) Ensembl	Ensembl	2,926 nt	Select Tool
mRNA	kalrnb-202 (1) Ensembl	Ensembl	751 nt	Select Tool
mRNA	kalrnb-203 (1) Ensembl	Ensembl	3,123 nt	Select Tool
mRNA	kalrnb-204 (1) Ensembl	Ensembl	7,965 nt	Select Tool
mRNA	kalrnb-205 (1) Ensembl	Ensembl	8,639 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations