Gene

gale

ID
ZDB-GENE-060421-6479
Name
UDP-galactose-4-epimerase
Symbol
gale Nomenclature History
Previous Names
  • fb05f01
  • im:7147391
  • wu:fb05f01
  • zgc:136578
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable UDP-glucose 4-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose. Predicted to act upstream of or within galactose metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in galactose epimerase deficiency and thrombocytopenia. Orthologous to human GALE (UDP-galactose-4-epimerase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la020017TgTransgenic insertionUnknownUnknownDNA
sa13754Allele with one point mutationUnknownSplice SiteENU
sa17133Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With gale Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
galactose epimerase deficiency Alliance Galactose epimerase deficiency 230350
Thrombocytopenia 13, syndromic 620776
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Associated With gale Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR016040 NAD(P)-binding domain
Family IPR005886 UDP-glucose 4-epimerase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length NAD(P)-binding domain NAD(P)-binding domain superfamily UDP-glucose 4-epimerase
UniProtKB:F1Q5H4 InterPro 350
UniProtKB:Q1RM15 InterPro 349
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gale-201 (1) Ensembl 1,527 nt
mRNA gale-202 (1) Ensembl 877 nt
mRNA gale-203 (1) Ensembl 1,430 nt
mRNA gale-204 (1) Ensembl 4,301 nt
mRNA gale-205 (1) Ensembl 1,522 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-195O20ZFIN Curated Data
EncodesESTfb05f01
EncodesESTIMAGE:7147391Thisse et al., 2004
EncodescDNAMGC:136578ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGALE1
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseGale4
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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