Gene
pitx1
- ID
- ZDB-GENE-060421-3623
- Name
- paired-like homeodomain 1
- Symbol
- pitx1 Nomenclature History
- Previous Names
-
- zgc:136976 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including adenohypophyseal placode; head; immature eye; non neural ectoderm; and pelvic fin bud. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human PITX1 (paired like homeodomain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein Pitx/unc30 | Homeodomain | OAR domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P3F1
|
285 | |||||
|
UniProtKB:A9Y0D5
|
285 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available