ZFIN ID: ZDB-GENE-060421-3470
Gene Name: folliculin
Gene Symbol: flcn    Nomenclature History

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Previous Names: wu:fe38g11, zgc:136982

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of GTPase activity; and positive regulation of signal transduction. Predicted to localize to cytosol. Is expressed in brain; hatching gland; pectoral fin bud; retina; and tail bud. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin).
Genome Resources: Alliance (1),  Gene:678628 (1),  Ensembl(GRCz11):ENSDARG00000062385 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
e36 Point Mutation Unknown Premature Stop
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-flcn N/A 1
    MO2-flcn N/A 1
    MO3-flcn N/A 1
    DISEASE ASSOCIATED WITH flcn HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Birt-Hogg-Dube syndrome Alliance Birt-Hogg-Dube syndrome 135150
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    nonpapillary renal cell carcinoma Alliance Renal carcinoma, chromophobe, somatic 144700
    primary spontaneous pneumothorax Alliance Pneumothorax, primary spontaneous 173600
    DISEASE ASSOCIATED WITH flcn VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Birt-Hogg-Dube syndrome AB + MO3-flcn standard conditions Kenyon et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription by RNA polymerase II (more)
    Cellular Component cytosol (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA flcn-201 (1)    Ensembl 2468
    flcn-202 (1)    Ensembl 780
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM flcn No data available
    MARKER RELATIONSHIPS
    flcn Contained in: [BAC] CH211-149K23 (1)
    flcn Encodes: [EST] fe38g11
    [cDNA] MGC:136982 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040373 (1) 2493 nt
    Genomic GenBank:CU459065 (1) 150935 nt
    Select Tool
    Polypeptide UniProtKB:F1R3E5 (1) 558 aa
    Sequence Information (all 13)
    ORTHOLOGY for flcn ( Chr: 16 )
    CITATIONS (25)