Gene
baiap2a
- ID
- ZDB-GENE-060421-2756
- Name
- BAR/IMD domain containing adaptor protein 2a
- Symbol
- baiap2a Nomenclature History
- Previous Names
-
- wu:fk29g02
- zgc:136827
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cytoskeletal anchor activity. Predicted to be involved in actin crosslink formation; actin filament bundle assembly; and positive regulation of actin filament polymerization. Predicted to act upstream of or within plasma membrane organization and regulation of actin cytoskeleton organization. Predicted to be located in several cellular components, including cytoskeleton; filopodium; and ruffle. Predicted to be active in cytosol and nucleoplasm. Is expressed in dorsal telencephalon. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015260Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024288Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028942Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8395 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9258 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11319 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33307 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33308 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40162 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 9 of 9
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR013606 | IMD/I-BAR domain |
| Domain | IPR030128 | BAR/IMD domain-containing adapter protein 2, I-BAR domain |
| Domain | IPR035594 | BAR/IMD domain-containing adapter protein 2, SH3 domain |
| Family | IPR027681 | I-BAR domain containing protein IRSp53/IRTKS/Pinkbar |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | BAR/IMD domain-containing adapter protein 2, I-BAR domain | BAR/IMD domain-containing adapter protein 2, SH3 domain | I-BAR domain containing protein IRSp53/IRTKS/Pinkbar | IMD/I-BAR domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AQY0 | InterPro | 485 | |||||||
| UniProtKB:A0A8M9PQ60 | InterPro | 536 | |||||||
| UniProtKB:Q1RLU7 | InterPro | 506 | |||||||
| UniProtKB:A0A8M2BAV5 | InterPro | 549 | |||||||
| UniProtKB:A0A8M3B8K0 | InterPro | 465 | |||||||
| UniProtKB:A0A8M1N8M4 | InterPro | 514 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
baiap2a-201
(1)
|
Ensembl | 2,698 nt | ||
| mRNA |
baiap2a-202
(1)
|
Ensembl | 3,391 nt | ||
| mRNA |
baiap2a-203
(1)
|
Ensembl | 4,757 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(5xUAS:dnbaiap2a-2A-TagRFP) |
| 1 | Qi et al., 2022 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207C1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-29J19 | ZFIN Curated Data | |
| Encodes | EST | fk29g02 | ||
| Encodes | cDNA | MGC:136827 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040245 (1) | 3477 nt | ||
| Genomic | GenBank:BX547935 (1) | 195252 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAV5 (1) | 549 aa |
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Qi, J., Rittershaus, A., Priya, R., Mansingh, S., Stainier, D.Y.R., Helker, C.S.M. (2022) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. eLIFE. 11:
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Desban, L., Prendergast, A., Roussel, J., Rosello, M., Geny, D., Wyart, C., Bardet, P.L. (2019) Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology. 17:e3000235
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44
- Willi, R.A., Faltermann, S., Hettich, T., Fent, K. (2017) Active glucocorticoids have a range of important adverse developmental and physiological effects on developing zebrafish embryos. Environmental science & technology. 52(2):877-885
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Chen, Q., Jia, A., Snyder, S.A., Gong, Z., Lam, S.H. (2016) Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 144:1162-1169
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 10 of 14
Show