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Gene

phf8

ID
ZDB-GENE-060419-1
Name
PHD finger protein 8
Symbol
phf8 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable chromatin binding activity; histone demethylase activity; and methylated histone binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within brain development; embryonic organ development; and regulation of neuron apoptotic process. Predicted to be located in nucleolus. Is expressed in head; mandibular arch skeleton; and tail bud. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Siderius type. Orthologous to human PHF8 (PHD finger protein 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Qi et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Qi et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With phf8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
syndromic X-linked intellectual disability Siderius type Alliance Intellectual developmental disorder, X-linked, syndromic, Siderius type 300263
Associated With phf8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019786 Zinc finger, PHD-type, conserved site
Domain IPR001965 Zinc finger, PHD-type
Domain IPR003347 JmjC domain
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR041070 Jumonji, helical domain
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Domain Details Per Protein
Protein Length JmjC domain Jumonji, helical domain Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, PHD-type, conserved site Zinc finger, RING/FYVE/PHD-type
UniProtKB:P0CH95
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations