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ZIRC
ZFIN ID: ZDB-GENE-060419-1
Gene Name: PHD finger protein 8
Gene Symbol: phf8    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity; histone demethylase activity; and methylated histone binding activity. Involved in several processes, including embryonic organ development; positive regulation of transcription, DNA-templated; and regulation of neuron apoptotic process. Predicted to localize to the nucleolus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Siderius type. Is expressed in head; mandibular arch skeleton; and tail bud. Orthologous to human PHF8 (PHD finger protein 8).
Genome Resources: Alliance (1),  Gene:566534 (1),  Ensembl(GRCz11):ENSDARG00000006584 (2)
GENE EXPRESSION
All Expression Data: Fig. S12 from Qi et al., 2010
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7309 Point Mutation Unknown Splice Site ENU
sa9816 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-phf8
    1
    CRISPR2-phf8
    1
    MO1-phf8 N/A 1
    MO2-phf8 N/A 1
    MO3-phf8 N/A 1
    DISEASE ASSOCIATED WITH phf8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    syndromic X-linked intellectual disability Siderius type Alliance Mental retardation syndrome, X-linked, Siderius type 300263
    DISEASE ASSOCIATED WITH phf8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component nucleolus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 24)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA phf8-201 (1)    Ensembl 4129
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM phf8 No data available
    MARKER RELATIONSHIPS
    phf8 Contained in: [BAC] DKEY-166N8 (1) (order this)
    phf8 Encodes: [EST] wz12055
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001202447 (1) 4821 bp
    Genomic GenBank:CR352210 (1) 180924 bp
    Select Tool
    Polypeptide UniProtKB:P0CH95 (1)
    Sequence Clusters UniGene:104540 (1)
    Sequence Information (all 11)
    ORTHOLOGY for phf8 ( Chr: 23 )
    CITATIONS (20)