Gene

nfs1

ID

ZDB-GENE-060405-1

Name

NFS1 cysteine desulfurase

Symbol

nfs1 Nomenclature History

Previous Names

fb50g03
wu:fb50g03

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have cysteine desulfurase activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to localize to cytosol; mitochondrion; and nucleus. Orthologous to human NFS1 (NFS1 cysteine desulfurase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfs1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 52	Alliance	Combined oxidative phosphorylation deficiency 52	619386

Associated With nfs1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020578	Aminotransferase class-V, pyridoxal-phosphate binding site
Domain	IPR000192	Aminotransferase class V domain
Family	IPR010240	Cysteine desulfurase IscS
Family	IPR016454	Cysteine desulfurase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase