ZFIN is now using GRCz12tu for Genomic Data
Gene
arhgef7a
- ID
- ZDB-GENE-060322-11
- Name
- Rho guanine nucleotide exchange factor (GEF) 7a
- Symbol
- arhgef7a Nomenclature History
- Previous Names
-
- fc28d09
- wu:fc28d09
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm and lamellipodium. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144067 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000219 | Dbl homology domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR032409 | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain |
| Domain | IPR035788 | Rho guanine nucleotide exchange factor 6, SH3 domain |
| Domain | IPR046376 | RhoGEF 6/7, PH domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | CH domain superfamily | Dbl homology (DH) domain superfamily | Dbl homology domain | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | RhoGEF 6/7, PH domain | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain | Rho guanine nucleotide exchange factor 6, SH3 domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S771 | InterPro | 858 | ||||||||||||
| UniProtKB:A0A8M9QJM4 | InterPro | 702 | ||||||||||||
| UniProtKB:A0A2R8Q515 | InterPro | 859 | ||||||||||||
| UniProtKB:A0A8M6Z2J5 | InterPro | 782 | ||||||||||||
| UniProtKB:A0A8M2BF23 | InterPro | 807 | ||||||||||||
| UniProtKB:A0A8M2BF17 | InterPro | 777 | ||||||||||||
| UniProtKB:A0A8M9Q4K4 | InterPro | 864 | ||||||||||||
| UniProtKB:A0A8M2BEZ3 | InterPro | 802 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef7a-202
(1)
|
Ensembl | 3,312 nt | ||
| mRNA |
arhgef7a-204
(1)
|
Ensembl | 6,971 nt | ||
| ncRNA |
arhgef7a-002
(1)
|
Ensembl | 2,491 nt | ||
| ncRNA |
arhgef7a-003
(1)
|
Ensembl | 556 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers