Gene
cog4
- ID
- ZDB-GENE-060312-33
- Name
- component of oligomeric golgi complex 4
- Symbol
- cog4 Nomenclature History
- Previous Names
-
- zgc:136860
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Acts upstream of or within proteoglycan metabolic process and skeletal system development. Predicted to be located in Golgi membrane and cytosol. Predicted to be part of Golgi transport complex. Is expressed in nervous system; otic epithelium; otic vesicle protrusion; and pharyngeal arch cartilage. Used to study Saul-Wilson syndrome. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital disorder of glycosylation type IIj | Alliance | Congenital disorder of glycosylation, type IIj | 613489 |
| Saul-Wilson syndrome | Alliance | Saul-Wilson syndrome | 618150 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Saul-Wilson syndrome | cog4b1312/b1312 | standard conditions | Ferreira et al., 2018 |
| Saul-Wilson syndrome | cog4b1311/b1311 | standard conditions | Ferreira et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013167 | COG4 transport protein, middle alpha-helical bundle |
| Domain | IPR048680 | Conserved oligomeric Golgi complex subunit 4, N-terminal |
| Domain | IPR048684 | Conserved oligomeric Golgi complex subunit 4, C-terminal |
| Family | IPR048682 | Conserved oligomeric Golgi complex subunit 4 |
Domain Details Per Protein
| Protein | Length | COG4 transport protein, middle alpha-helical bundle | Conserved oligomeric Golgi complex subunit 4 | Conserved oligomeric Golgi complex subunit 4, C-terminal | Conserved oligomeric Golgi complex subunit 4, N-terminal |
|---|---|---|---|---|---|
|
UniProtKB:Q29RB1
|
781 |
Interactions and Pathways
No data available
Plasmids
No data available