Gene

lgi1b

ID

ZDB-GENE-060217-1

Name

leucine-rich, glioma inactivated 1b

Symbol

lgi1b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Involved in brain morphogenesis and myelination. Human ortholog(s) of this gene implicated in childhood absence epilepsy and familial temporal lobe epilepsy 1. Is expressed in brain; eye; head mesenchyme; heart; and skeletal muscle. Orthologous to several human genes including LGI1 (leucine rich glioma inactivated 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Teng et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lgi1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial temporal lobe epilepsy 1	Alliance	Epilepsy, familial temporal lobe, 1	600512

Associated With lgi1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Family	IPR051295	Leucine-rich glioma-inactivated/LGI-related
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype
Repeat	IPR005492	Leucine-rich glioma-inactivated , EPTP repeat
Repeat	IPR009039	EAR