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Gene

atp5fa1

ID
ZDB-GENE-060201-1
Name
ATP synthase F1 subunit alpha
Symbol
atp5fa1 Nomenclature History
Previous Names
  • atp5a1
  • zgc:154103
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Enables lipoteichoic acid binding activity. Acts upstream of or within with a positive effect on defense response to bacterium. Predicted to be located in membrane. Predicted to be part of mitochondrial proton-transporting ATP synthase, catalytic core. Is expressed in several structures, including digestive system; fin; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22 and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp5fa1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 22 Alliance ?Combined oxidative phosphorylation deficiency 22 616045
mitochondrial complex V (ATP synthase) deficiency nuclear type 4 Alliance ?Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4 615228
Associated With atp5fa1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Domain IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Domain IPR000793 ATP synthase, alpha subunit, C-terminal
Domain IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Domain IPR033732 ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
Family IPR005294 ATP synthase, F1 complex, alpha subunit
Homologous_superfamily IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Homologous_superfamily IPR038376 ATP synthase, alpha subunit, C-terminal domain superfamily
Domain Details Per Protein
Protein Length ATPase, alpha/beta subunit, nucleotide-binding domain, active site ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain ATP synthase, alpha subunit, C-terminal ATP synthase, alpha subunit, C-terminal domain superfamily ATP synthase, F1 complex, alpha subunit ATP synthase, F1 complex, alpha subunit nucleotide-binding domain ATP synthase subunit alpha, N-terminal domain-like superfamily P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q08BA1 551
UniProtKB:Q58P23 236
UniProtKB:Q6EE37 364
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-atp5a1 monoclonal IgG2b , k Mouse
  • WB
MitoSciences
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations