Gene
dock4b
- ID
- ZDB-GENE-060130-74
- Name
- dedicator of cytokinesis 4b
- Symbol
- dock4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in cell chemotaxis. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human DOCK4 (dedicator of cytokinesis 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu488 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024729Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024730Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12293 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14015 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15932 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16113 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16345 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17211 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20201 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20202 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | C2 DOCK-type domain | C2 domain superfamily | Dedicator of cytokinesis | Dedicator of cytokinesis 4, SH3 domain | Dedicator of cytokinesis B, C2 domain | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | Dedicator of cytokinesis, N-terminal domain | Dedicator of cytokinesis, N-terminal, subdomain 1 | Dedicator of cytokinesis protein 4, DHR2 domain | Dedicator of cytokinesis, TPR repeats region | DOCKER domain | DOCKER, Lobe B | DOCKER, Lobe C | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A286Y8M9 | InterPro | 1953 | |||||||||||||||||
| UniProtKB:A0A8M2BC66 | InterPro | 1930 | |||||||||||||||||
| UniProtKB:E9QJL8 | InterPro | 1977 | |||||||||||||||||
| UniProtKB:A0A8M2BC62 | InterPro | 1970 | |||||||||||||||||
| UniProtKB:A0A8M2BC87 | InterPro | 1938 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dock4b-201
(1)
|
Ensembl | 6,111 nt | ||
| mRNA |
dock4b-203
(1)
|
Ensembl | 5,451 nt | ||
| mRNA |
dock4b-204
(1)
|
Ensembl | 10,118 nt | ||
| mRNA |
dock4b-205
(1)
|
Ensembl | 10,177 nt | ||
| mRNA |
dock4b-206
(1)
|
Ensembl | 10,150 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-238A11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-284E3 | ZFIN Curated Data | |
| Encodes | EST | eu488 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166228 (1) | 6111 nt | ||
| Genomic | GenBank:CR388190 (1) | 122153 nt | ||
| Polypeptide | UniProtKB:E9QJL8 (1) | 1977 aa |
- Zhu, Z., Liu, Y., Xu, W., Liu, T., Xie, Y., Sham, K.W.Y., Sha, O., Cheng, C.H.K. (2020) Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Frontiers in genetics. 11:299
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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