ZFIN is now using GRCz12tu for Genomic Data
Gene
masp2
- ID
- ZDB-GENE-060130-154
- Name
- MBL associated serine protease 2
- Symbol
- masp2 Nomenclature History
- Previous Names
-
- sb:eu714
- wu:fb62a09
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in complement activation and proteolysis. Predicted to be active in extracellular region. Is expressed in liver. Orthologous to human MASP2 (MBL associated serine protease 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu714 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| MASP2 deficiency | 613791 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR049883 | NOTCH1, EGF-like calcium-binding domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR024175 | Peptidase S1A, complement C1r/C1S/mannan-binding |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CUB domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | NOTCH1, EGF-like calcium-binding domain | Peptidase S1A, chymotrypsin family | Peptidase S1A, complement C1r/C1S/mannan-binding | Peptidase S1, PA clan | Serine proteases, trypsin domain | Serine proteases, trypsin family, serine active site | Spermadhesin, CUB domain superfamily | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NGF4 | InterPro | 684 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers