Gene
casz1
- ID
- ZDB-GENE-060130-108
- Name
- castor zinc finger 1
- Symbol
- casz1 Nomenclature History
- Previous Names
-
- sb:eu580
- wu:fk85f10
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; cardiovascular system; hindbrain neural plate; musculature system; and nervous system. Orthologous to human CASZ1 (castor zinc finger 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu580 (29 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mn0001Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1888 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14282 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37743 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44005 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor castor | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:A0A8M2B961 | InterPro | 2001 | ||
| UniProtKB:A0A8M9PFJ4 | InterPro | 2000 | ||
| UniProtKB:A0A8M2B9I3 | InterPro | 2011 | ||
| UniProtKB:A0A8M2B956 | InterPro | 2005 | ||
| UniProtKB:A0A8M9PL89 | InterPro | 1910 | ||
| UniProtKB:A0A8M3B6A1 | InterPro | 2022 | ||
| UniProtKB:A0A8M9PWX4 | InterPro | 1231 | ||
| UniProtKB:A0AB32TAW5 | InterPro | 1970 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-87A15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-203C4 | ZFIN Curated Data | |
| Encodes | EST | eu580 | Thisse et al., 2005 | |
| Encodes | EST | fk85f10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009296966 (1) | 9103 nt | ||
| Genomic | GenBank:CR376756 (2) | 203373 nt | ||
| Polypeptide | UniProtKB:A0A8M3B6A1 (1) | 2022 aa |
- Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
- Szenker-Ravi, E., Ott, T., Khatoo, M., de Bellaing, A.M., Goh, W.X., Chong, Y.L., Beckers, A., Kannesan, D., Louvel, G., Anujan, P., Ravi, V., Bonnard, C., Moutton, S., Schoen, P., Fradin, M., Colin, E., Megarbane, A., Daou, L., Chehab, G., Di Filippo, S., Rooryck, C., Deleuze, J.F., Boland, A., Arribard, N., Eker, R., Tohari, S., Ng, A.Y., Rio, M., Lim, C.T., Eisenhaber, B., Eisenhaber, F., Venkatesh, B., Amiel, J., Crollius, H.R., Gordon, C.T., Gossler, A., Roy, S., Attie-Bitach, T., Blum, M., Bouvagnet, P., Reversade, B. (2021) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nature Genetics. 54(1):62-72
- Krug, R.G., Lee, H.B., El Khoury, L.Y., Sigafoos, A.N., Petersen, M.O., Clark, K.J. (2018) The endocannabinoid gene faah2a modulates stress-associated behavior in zebrafish. PLoS One. 13:e0190897
- Ding, Y., Long, P.A., Bos, J.M., Shih, Y.H., Ma, X., Sundsbak, R.S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M.J., Lin, X., Ekker, S.C., Redfield, M.M., Olson, T.M., Xu, X. (2016) A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.. JCI insight. 1(14)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Clark, K.J., Balciunas, D., Pogoda, H.M., Ding, Y., Westcot, S.E., Bedell, V.M., Greenwood, T.M., Urban, M.D., Skuster, K.J., Petzold, A.M., Ni, J., Nielsen, A.L., Patowary, A., Scaria, V., Sivasubbu, S., Xu, X., Hammerschmidt, M., and Ekker, S.C. (2011) In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nature Methods. 8(6):506-512
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