Gene
irgq1
- ID
- ZDB-GENE-051212-3
- Name
- immunity-related GTPase family, q1
- Symbol
- irgq1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity. Predicted to be located in membrane.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sieger et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa36139 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunity-related GTPase | Immunity-related GTPases-like | IRG-type guanine nucleotide-binding (G) domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:X1WE34 | InterPro | 493 | ||||
| UniProtKB:A0AB40E6S7 | InterPro | 526 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-175G6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_688591 (1) | 2337 nt | ||
| Genomic | GenBank:CR391937 (1) | 224481 nt | ||
| Polypeptide | UniProtKB:A0AB40E6S7 (1) | 526 aa |
No data available
- Ding, Y., Tong, J., Luo, G., Sun, R., Bei, C., Feng, Z., Meng, L., Wang, F., Zhou, J., Chen, Z., Li, D., Fan, Y., Song, S., Wang, D., Feng, C.G., Liu, H., Chen, Q., Yan, B., Gao, Q. (2024) Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway. iScience. 27:109807109807
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sieger, D., Stein, C., Neifer, D., van der Sar, A.M., and Leptin, M. (2009) The role of gamma interferon in innate immunity in the zebrafish embryo. Disease models & mechanisms. 2(11-12):571-581
- Bekpen, C., Hunn, J.P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D.M., Glowalla, E., Leptin, M., and Howard, J.C. (2005) The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome biology. 6(11):R92
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