ZFIN is now using GRCz12tu for Genomic Data
Gene
grin1a
- ID
- ZDB-GENE-051202-1
- Name
- glutamate receptor, ionotropic, N-methyl D-aspartate 1a
- Symbol
- grin1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ligand-gated monoatomic ion channel activity and signaling receptor activity. Predicted to contribute to NMDA glutamate receptor activity. Predicted to be involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zoodsma et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 8 | Alliance | Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant | 614254 |
| developmental and epileptic encephalopathy 101 | Alliance | Developmental and epileptic encephalopathy 101 | 619814 |
| Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive | 617820 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Domain | IPR049872 | Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain |
| Domain | IPR049873 | Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grin1a-201
(1)
|
Ensembl | 1,248 nt | ||
| mRNA |
grin1a-202
(1)
|
Ensembl | 4,549 nt | ||
| mRNA |
grin1a-203
(1)
|
Ensembl | 2,847 nt | ||
| mRNA |
grin1a-204
(1)
|
Ensembl | 2,933 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers