Gene
grin1a
- ID
- ZDB-GENE-051202-1
- Name
- glutamate receptor, ionotropic, N-methyl D-aspartate 1a
- Symbol
- grin1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables ligand-gated monoatomic ion channel activity. Involved in calcium ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zoodsma et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| s3019 | Allele with one deletion | Exon 2 | Unknown | not specified | |
| sa133 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7245 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25151 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37246 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sbu90 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| sbu91 | Allele with one delins | Unknown | Premature Stop | CRISPR | |
| sbu92 | Allele with one deletion | Unknown | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-grin1a | Gao et al., 2018 | |
| CRISPR2-grin1a | (3) | |
| CRISPR3-grin1a | Griffin et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 8 | Alliance | Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant | 614254 |
| developmental and epileptic encephalopathy 101 | Alliance | Developmental and epileptic encephalopathy 101 | 619814 |
| Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive | 617820 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Domain | IPR049872 | Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain |
| Domain | IPR049873 | Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain | Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B7Z5 | InterPro | 880 | ||||||||
| UniProtKB:F1R366 | InterPro | 901 | ||||||||
| UniProtKB:A0A8M2B802 | InterPro | 914 | ||||||||
| UniProtKB:A0A8M2B7Z4 | InterPro | 951 | ||||||||
| UniProtKB:A0A8M9PCT9 | InterPro | 938 | ||||||||
| UniProtKB:A0A8M9PQL9 | InterPro | 942 | ||||||||
| UniProtKB:A0A8M3ALB6 | InterPro | 930 | ||||||||
| UniProtKB:A0A8M3ATQ3 | InterPro | 947 | ||||||||
| UniProtKB:A0A8M2B7Z7 | InterPro | 905 | ||||||||
| UniProtKB:A0A8M9PIG4 | InterPro | 917 | ||||||||
| UniProtKB:A0A8M3B4K1 | InterPro | 926 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grin1a-201
(1)
|
Ensembl | 1,248 nt | ||
| mRNA |
grin1a-202
(1)
|
Ensembl | 4,549 nt | ||
| mRNA |
grin1a-203
(1)
|
Ensembl | 2,847 nt | ||
| mRNA |
grin1a-204
(1)
|
Ensembl | 2,933 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-184P9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152678 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001076714 (1) | 3235 nt | ||
| Genomic | GenBank:BX005379 (2) | 185814 nt | ||
| Polypeptide | UniProtKB:A0A8M2B7Z4 (1) | 951 aa |
- Baker, C.E., Marta, A.G., Zimmerman, N.D., Korade, Z., Mathy, N.W., Wilton, D., Simeone, T., Kochvar, A., Kramer, K.L., Stessman, H.A.F., Shibata, A. (2024) CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 14(8):
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Napoli, A.J., Laderwager, S., Zoodsma, J.D., Biju, B., Mucollari, O., Schubel, S.K., Aprea, C., Sayed, A., Morgan, K., Napoli, A., Flanagan, S., Wollmuth, L.P., Sirotkin, H.I. (2024) Developmental loss of NMDA receptors results in supernumerary forebrain neurons through delayed maturation of transit-amplifying neuroblasts. Scientific Reports. 14:33953395
- Moraes, I.B., Paiva, I.M., Moreira-Júnior, R.E., Sartori, B.M., Franco, R.R., Espindola, F.S., Murgas, L.D.S., Brunialti-Godard, A.L. (2023) Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains. Frontiers in bioscience (Landmark edition). 28:7373
- Simonian, R., Pannia, E., Hammoud, R., Noche, R.R., Cui, X., Kranenburg, E., Kubant, R., Ashcraft, P., Wasek, B., Bottiglieri, T., Dowling, J.J., Anderson, G.H. (2023) Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish. Human molecular genetics. 32(9):1575-1588
- Tang, S.L., Liang, X.F., He, S., Li, L., Alam, M.S., Wu, J. (2022) Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Frontiers in genetics. 13:909091
- Zoodsma, J.D., Keegan, E.J., Moody, G.R., Bhandiwad, A.A., Napoli, A.J., Burgess, H.A., Wollmuth, L.P., Sirotkin, H.I. (2022) Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish. Molecular autism. 13:38
- Atzei, A., Jense, I., Zwart, E.P., Legradi, J., Venhuis, B.J., van der Ven, L.T.M., Heusinkveld, H.J., Hessel, E.V.S. (2021) Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test. International Journal of Environmental Research and Public Health. 18(13):
- Buchumenski, I., Holler, K., Appelbaum, L., Eisenberg, E., Junker, J.P., Levanon, E.Y. (2021) Systematic identification of A-to-I RNA editing in zebrafish development and adult organs. Nucleic acids research. 49(8):4325-4337
- Gawel, K., Kukula-Koch, W., Banono, N.S., Nieoczym, D., Targowska-Duda, K.M., Czernicka, L., Parada-Turska, J., Esguerra, C.V. (2021) 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. International Journal of Molecular Sciences. 22(14):
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