Gene

grin1a

ID

ZDB-GENE-051202-1

Name

glutamate receptor, ionotropic, N-methyl D-aspartate 1a

Symbol

grin1a Nomenclature History

Previous Names

NMDA receptor glycine-binding subunit NR1.1 (1)
NMDAR1.1 (1)
zgc:152678

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Enables ligand-gated monoatomic ion channel activity. Involved in calcium ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Zoodsma et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grin1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 8	Alliance	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	614254
developmental and epileptic encephalopathy 101	Alliance	Developmental and epileptic encephalopathy 101	619814
		Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	617820

Associated With grin1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Domain	IPR049872	Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain
Domain	IPR049873	Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Length	Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain	Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain	Ionotropic glutamate receptor	Ionotropic glutamate receptor, C-terminal	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain	Ionotropic glutamate receptor, metazoa	Periplasmic binding protein-like I	Receptor, ligand binding region
UniProtKB:A0A8M2B7Z5 InterPro	880
UniProtKB:F1R366 InterPro	901
UniProtKB:A0A8M2B802 InterPro	914
UniProtKB:A0A8M2B7Z4 InterPro	951
UniProtKB:A0A8M9PCT9 InterPro	938
UniProtKB:A0A8M9PQL9 InterPro	942
UniProtKB:A0A8M3ALB6 InterPro	930
UniProtKB:A0A8M3ATQ3 InterPro	947
UniProtKB:A0A8M2B7Z7 InterPro	905
UniProtKB:A0A8M9PIG4 InterPro	917
UniProtKB:A0A8M3B4K1 InterPro	926

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	grin1a-201 (1) Ensembl	Ensembl	1,248 nt	Select Tool ZFIN BLAST
mRNA	grin1a-202 (1) Ensembl	Ensembl	4,549 nt	Select Tool ZFIN BLAST
mRNA	grin1a-203 (1) Ensembl	Ensembl	2,847 nt	Select Tool ZFIN BLAST
mRNA	grin1a-204 (1) Ensembl	Ensembl	2,933 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations