Gene
grin1a
- ID
- ZDB-GENE-051202-1
- Name
- glutamate receptor, ionotropic, N-methyl D-aspartate 1a
- Symbol
- grin1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to contribute to NMDA glutamate receptor activity. Predicted to be involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Predicted to localize to NMDA selective glutamate receptor complex; neuron projection; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zoodsma et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant intellectual developmental disorder 8 | Alliance | Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant | 614254 |
Developmental and epileptic encephalopathy 101 | 619814 | ||
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive | 617820 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001320 | Ionotropic glutamate receptor |
Domain | IPR001828 | Receptor, ligand binding region |
Domain | IPR018882 | Calmodulin-binding domain C0, NMDA receptor, NR1 subunit |
Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
Family | IPR000337 | GPCR, family 3 |
Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
Protein | Length | Calmodulin-binding domain C0, NMDA receptor, NR1 subunit | GPCR, family 3 | Ionotropic glutamate receptor | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0B5JFI5
|
226 | |||||||
UniProtKB:E7F101
|
966 | |||||||
UniProtKB:Q1RM76
|
191 | |||||||
UniProtKB:Q08CV1
|
226 | |||||||
UniProtKB:E7EYT4
|
938 | |||||||
UniProtKB:F1R366
|
901 | |||||||
UniProtKB:Q504C5
|
195 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
grin1a-201
(1)
|
1248 nt | |
mRNA |
grin1a-202
(1)
|
4549 nt | |
mRNA |
grin1a-203
(1)
|
2847 nt | |
mRNA |
grin1a-204
(1)
|
2933 nt |
Interactions and Pathways
No data available
Plasmids
No data available