Gene

grin1a

ID

ZDB-GENE-051202-1

Name

glutamate receptor, ionotropic, N-methyl D-aspartate 1a

Symbol

grin1a Nomenclature History

Previous Names

NMDA receptor glycine-binding subunit NR1.1 (1)
NMDAR1.1 (1)
zgc:152678

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to contribute to NMDA glutamate receptor activity. Predicted to be involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Predicted to localize to NMDA selective glutamate receptor complex; neuron projection; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Zoodsma et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grin1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 8	Alliance	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	614254
		Developmental and epileptic encephalopathy 101	619814
		Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	617820

Associated With grin1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR018882	Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR000337	GPCR, family 3
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Length	Calmodulin-binding domain C0, NMDA receptor, NR1 subunit	GPCR, family 3	Ionotropic glutamate receptor	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain	Ionotropic glutamate receptor, metazoa	Periplasmic binding protein-like I	Receptor, ligand binding region
UniProtKB:A0A0B5JFI5 InterPro	226
UniProtKB:E7F101 InterPro	966
UniProtKB:Q1RM76 InterPro	191
UniProtKB:Q08CV1 InterPro	226
UniProtKB:E7EYT4 InterPro	938
UniProtKB:F1R366 InterPro	901
UniProtKB:Q504C5 InterPro	195

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	grin1a-201 (1) Ensembl	1248 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	grin1a-202 (1) Ensembl	4549 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	grin1a-203 (1) Ensembl	2847 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	grin1a-204 (1) Ensembl	2933 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations