Gene

grin1a

ID
ZDB-GENE-051202-1
Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
Symbol
grin1a Nomenclature History
Previous Names
  • NMDA receptor glycine-binding subunit NR1.1 (1)
  • NMDAR1.1 (1)
  • zgc:152678
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to contribute to NMDA glutamate receptor activity. Predicted to be involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Predicted to localize to NMDA selective glutamate receptor complex; neuron projection; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Zoodsma et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grin1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 8 Alliance Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 614254
developmental and epileptic encephalopathy 101 Alliance Developmental and epileptic encephalopathy 101 619814
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive 617820
Associated With grin1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001320 Ionotropic glutamate receptor, C-terminal
Domain IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
Domain IPR001828 Receptor, ligand binding region
Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Domain IPR049872 Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain
Domain IPR049873 Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain
Family IPR001508 Ionotropic glutamate receptor, metazoa
Family IPR015683 Ionotropic glutamate receptor
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain Ionotropic glutamate receptor Ionotropic glutamate receptor, C-terminal Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Ionotropic glutamate receptor, metazoa Periplasmic binding protein-like I Receptor, ligand binding region Solute-binding protein family 3/N-terminal domain of MltF
UniProtKB:A0A8M2B7Z5 880
UniProtKB:F1R366 901
UniProtKB:A0A8M2B802 914
UniProtKB:A0A8M2B7Z4 951
UniProtKB:A0A8M9PCT9 938
UniProtKB:A0A8M9PQL9 942
UniProtKB:A0A8M3ALB6 930
UniProtKB:A0A8M3ATQ3 947
UniProtKB:A0A8M2B7Z7 905
UniProtKB:A0A8M9PIG4 917
UniProtKB:A0A8M3B4K1 926
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations