Gene
slc7a7
- ID
- ZDB-GENE-051127-5
- Name
- solute carrier family 7 member 7
- Symbol
- slc7a7 Nomenclature History
- Previous Names
-
- unm t30713
- unm_t30713
- zgc:123300
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable L-amino acid transmembrane transporter activity and basic amino acid transmembrane transporter activity. Acts upstream of or within microglia development. Predicted to be located in membrane. Is expressed in brain; myeloid cell; and pancreatic D cell. Used to study lysinuric protein intolerance. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to human SLC7A7 (solute carrier family 7 member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011498Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15030 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44653 | Allele with one point mutation | Unknown | Unknown | ENU | |
| t30713 | Allele with one point mutation | Acceptor Splice Site of Intron 4 | Splice Site, Exon Loss of Exon 5, Frameshift, Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-slc7a7 | N/A | (3) |
| MO2-slc7a7 | N/A | Demy et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lysinuric protein intolerance | Alliance | Lysinuric protein intolerance | 222700 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| lysinuric protein intolerance | slc7a7t30713/t30713 | standard conditions | Rossi et al., 2015 |
| lysinuric protein intolerance | WT + MO1-slc7a7 | standard conditions | Rossi et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Amino acid/polyamine transporter I | Cellular Amino Acid Transporter |
|---|---|---|---|---|
| UniProtKB:Q2YDQ4 | InterPro | 501 | ||
| UniProtKB:A0A8M1N819 | InterPro | 501 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc7a7-201
(1)
|
Ensembl | 2,395 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(slc7a7:Citrine) |
|
| 1 | Grimm et al., 2023 | |
| Tg(slc7a7:Kaede) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-212K18 | ||
| Encodes | cDNA | MGC:123300 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037559 (1) | 2383 nt | ||
| Genomic | GenBank:CR847902 (1) | 226255 nt | ||
| Polypeptide | UniProtKB:A0A8M1N819 (1) | 501 aa |
- Grimm, L., Mason, E., Yu, H., Dudczig, S., Panara, V., Chen, T., Bower, N.I., Paterson, S., Rondon Galeano, M., Kobayashi, S., Senabouth, A., Lagendijk, A.K., Powell, J., Smith, K.A., Okuda, K.S., Koltowska, K., Hogan, B.M. (2023) Single-cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development. The EMBO journal. 42(11):e112590
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Bruckner, J.J., Stednitz, S.J., Grice, M.Z., Zaidan, D., Massaquoi, M.S., Larsch, J., Tallafuss, A., Guillemin, K., Washbourne, P., Eisen, J.S. (2022) The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons. PLoS Biology. 20:e3001838
- Cavone, L., McCann, T., Drake, L.K., Aguzzi, E.A., Oprişoreanu, A.M., Pedersen, E., Sandi, S., Selvarajah, J., Tsarouchas, T.M., Wehner, D., Keatinge, M., Mysiak, K.S., Henderson, B.E.P., Dobie, R., Henderson, N.C., Becker, T., Becker, C.G. (2021) A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord. Developmental Cell. 56(11):1617-1630.e6
- Zhou, Q., Lei, L., Zhang, H., Chiu, S.C., Gao, L., Yang, R., Wei, W., Peng, G., Zhu, X., Xiong, J.W. (2021) Proprotein Convertase Furina Is Required for Heart Development in Zebrafish. Journal of Cell Science. 134(21):
- Demy, D.L., Carrère, M., Noche, R., Tauzin, M., Le Bris, M., Baek, C., Leshchiner, I., Goessling, W., Herbomel, P. (2020) The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity. Journal of Cell Science. 133(20):
- Gestri, G., Bazin-Lopez, N., Scholes, C., Wilson, S.W. (2018) Cell Behaviors during Closure of the Choroid Fissure in the Developing Eye. Frontiers in Cellular Neuroscience. 12:42
- Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Oosterhof, N., Holtman, I.R., Kuil, L.E., van der Linde, H.C., Boddeke, E.W., Eggen, B.J., van Ham, T.J. (2017) Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Glia. 65(1):138-149
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