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ZIRC
ZFIN ID: ZDB-GENE-051127-5
Gene Name: solute carrier family 7 member 7
Gene Symbol: slc7a7    Nomenclature History

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Previous Names: unm t30713, unm_t30713, zgc:123300

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have L-amino acid transmembrane transporter activity. Involved in microglia development. Predicted to localize to the integral component of membrane. Used to study lysinuric protein intolerance. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Is expressed in brain; myeloid cell; and pancreatic D cell. Orthologous to human SLC7A7 (solute carrier family 7 member 7).
Genome Resources: Alliance (1),  Gene:641560 (1),  Ensembl(GRCz11):ENSDARG00000055226 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011498Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15030 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44653 Point Mutation Unknown Unknown ENU
    t30713 Point Mutation Acceptor Splice Site of Intron 4 Splice Site, Exon Loss of Exon 5, Frameshift, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc7a7 N/A 2
    DISEASE ASSOCIATED WITH slc7a7 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lysinuric protein intolerance Alliance Lysinuric protein intolerance 222700
    DISEASE ASSOCIATED WITH slc7a7 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    lysinuric protein intolerance slc7a7t30713/t30713 standard conditions Rossi et al., 2015
    WT + MO1-slc7a7 standard conditions Rossi et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process microglia development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane transporter activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002293 (1)
  • Pfam:PF13520 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc7a7-201 (1)    Ensembl 2395
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc7a7
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(slc7a7:Kaede) slc7a7 Kaede Danio rerio 1 2
    MARKER RELATIONSHIPS
    slc7a7 Contained in: [BAC] CH211-212K18 (order this)
    slc7a7 Encodes: [cDNA] MGC:123300 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001037559 (1) 2409 bp
    Genomic GenBank:CR847902 (1) 226255 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1R8V8 (1) 501 aa
    Sequence Clusters UniGene:86853 (1)
    Sequence Information (all 11)
    ORTHOLOGY for slc7a7 ( Chr: 7 )
    CITATIONS (31)