sspo

ID

ZDB-GENE-051114-1

Name

SCO-spondin

Symbol

sspo Nomenclature History

Previous Names

scospondin
subcommissural organ spondin (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Involved in spinal cord anterior/posterior patterning. Is expressed in Reissner's fiber; flexural organ; floor plate; presumptive floor plate; and subcommissural organ. Used to study idiopathic scoliosis and scoliosis. Orthologous to human SSPOP (SCO-spondin, pseudogene).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sspo Human Ortholog

No data available

Associated With sspo Via Experimental Models

Human Disease	Fish	Conditions	Citations
idiopathic scoliosis	sspo^{stl300/stl300}	standard conditions	Troutwine et al., 2020
idiopathic scoliosis	sspo^dmh4/+	standard conditions	Rose et al., 2020
idiopathic scoliosis	sspo^ut24Tg/+	standard conditions	Troutwine et al., 2020
idiopathic scoliosis	sspo^{stl297/stl297}	standard conditions	Troutwine et al., 2020
scoliosis	sspo^{stl300/stl300}	standard conditions	Gray et al., 2020
scoliosis	sspo^{stl297/stl297}	standard conditions	Gray et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000421	Coagulation factor 5/8, C-terminal domain
Domain	IPR001007	VWFC domain
Domain	IPR001846	von Willebrand factor, type D domain
Domain	IPR002919	Trypsin Inhibitor-like, cysteine rich domain
Domain	IPR006207	Cystine knot, C-terminal
Domain	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain
Domain	IPR044004	Spondin-like TSP1 domain
Family	IPR050780	Mucin/von Willebrand/Thrombospondin superfamily
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036084	Serine protease inhibitor-like superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat