Gene
tnikb
- ID
- ZDB-GENE-051113-320
- Name
- TRAF2 and NCK interacting kinase b
- Symbol
- tnikb Nomenclature History
- Previous Names
-
- im:6898857
- zgc:123033
- zgc:152783
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in several processes, including activation of protein kinase activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in central nervous system; neural plate; retina; and ventral mesoderm. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898857 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 54 | Alliance | Intellectual developmental disorder, autosomal recessive 54 | 617028 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001180 | Citron homology (CNH) domain |
| Family | IPR051700 | STE20 Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Citron homology (CNH) domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | STE20 Ser/Thr Protein Kinase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1N866
|
1329 | ||||||
|
UniProtKB:A0A8M9PG19
|
1450 | ||||||
|
UniProtKB:A0A8M9PLU4
|
1421 | ||||||
|
UniProtKB:A0A8M9PXJ4
|
1401 | ||||||
|
UniProtKB:A0A8M9P5X5
|
1332 | ||||||
|
UniProtKB:A0A8M9PG24
|
1303 | ||||||
|
UniProtKB:A0A8M9PU45
|
1360 | ||||||
|
UniProtKB:A0A8M2B9R1
|
1321 | ||||||
|
UniProtKB:A0A8M2B9T3
|
1292 | ||||||
|
UniProtKB:A0A8M2BA19
|
1439 |
Interactions and Pathways
No data available
Plasmids
No data available