Gene

tnikb

ID
ZDB-GENE-051113-320
Name
TRAF2 and NCK interacting kinase b
Symbol
tnikb Nomenclature History
Previous Names
  • im:6898857
  • zgc:123033
  • zgc:152783
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in central nervous system; neural plate; retina; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnikb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, autosomal recessive 54 617028
Associated With tnikb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001180 Citron homology (CNH) domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Citron homology (CNH) domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q5EAR9 332
UniProtKB:F1QQG8 543
UniProtKB:F1QAJ8 522
UniProtKB:Q08CR7 522
UniProtKB:A0A2R8Q5Z8 522
UniProtKB:Q32PQ9 537
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations