Gene
slc4a2a
- ID
- ZDB-GENE-051101-2
- Name
- solute carrier family 4 member 2a
- Symbol
- slc4a2a Nomenclature History
- Previous Names
-
- ae2
- slc4a2
- ae2.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables chloride:bicarbonate antiporter activity. Acts upstream of or within monoatomic anion transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including cardiovascular system; immature eye; midbrain neural rod; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in osteopetrosis. Orthologous to human SLC4A2 (solute carrier family 4 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu780 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Osteopetrosis, autosomal recessive 9 | 620366 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018241 | Anion exchange, conserved site |
| Domain | IPR011531 | Bicarbonate transporter-like, transmembrane domain |
| Domain | IPR013769 | Band 3 cytoplasmic domain |
| Family | IPR001717 | Anion exchange protein |
| Family | IPR003020 | Bicarbonate transporter, eukaryotic |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Anion exchange, conserved site | Anion exchange protein | Band 3 cytoplasmic domain | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PZ09 | InterPro | 1247 | ||||||
| UniProtKB:B0S7B8 | InterPro | 1228 | ||||||
| UniProtKB:Q3KVL6 | InterPro | 1228 | ||||||
| UniProtKB:A0AB32TYV0 | InterPro | 1245 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a2a-201
(1)
|
Ensembl | 6,619 nt | ||
| mRNA |
slc4a2a-202
(1)
|
Ensembl | 495 nt |
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Interactions and Pathways
No data available
Plasmids
No data available