Gene

shox

ID
ZDB-GENE-051030-21
Name
shox homeobox
Symbol
shox Nomenclature History
Previous Names
  • si:ch211-134k13.1 (1)
  • zgc:123182 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within bone mineralization; cell population proliferation; and pectoral fin development. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; pericardial region; pharyngeal arch; and pleuroperitoneal region. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Leri-Weill dyschondrosteosis and SHOX-related short stature. Orthologous to human SHOX (SHOX homeobox).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With shox Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leri-Weill dyschondrosteosis Alliance Leri-Weill dyschondrosteosis 127300
SHOX-related short stature Alliance Short stature, idiopathic familial 300582
Langer mesomelic dysplasia 249700
1 - 3 of 3
Associated With shox Via Experimental Models
Human Disease Fish Conditions Citations
Werner syndrome shoxsa41471/sa41471 standard conditions Tian et al., 2022
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR003654 OAR domain
Family IPR052631 Paired homeobox Bicoid subfamily
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Additional Resources Length Helix-turn-helix motif Homedomain-like superfamily Homeobox, conserved site Homeodomain OAR domain Paired homeobox Bicoid subfamily
UniProtKB:A0A8M2BFC1 InterPro 304
UniProtKB:B0S5T0 InterPro 285
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA shox-201 (1)
Ensembl
Ensembl 1,072 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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