shox

ID

ZDB-GENE-051030-21

Name

shox homeobox

Symbol

shox Nomenclature History

Previous Names

si:ch211-134k13.1 (1)
zgc:123182 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within bone mineralization; cell population proliferation; and pectoral fin development. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; pericardial region; pharyngeal arch; and pleuroperitoneal region. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Leri-Weill dyschondrosteosis and SHOX-related short stature. Orthologous to human SHOX (SHOX homeobox).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With shox Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Leri-Weill dyschondrosteosis	Alliance	Leri-Weill dyschondrosteosis	127300
SHOX-related short stature	Alliance	Short stature, idiopathic familial	300582
		Langer mesomelic dysplasia	249700

Associated With shox Via Experimental Models

Human Disease	Fish	Conditions	Citations
Werner syndrome	shox^{sa41471/sa41471}	standard conditions	Tian et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR003654	OAR domain
Family	IPR052631	Paired homeobox Bicoid subfamily
Homologous_superfamily	IPR009057	Homedomain-like superfamily