Gene
kitb
- ID
- ZDB-GENE-050916-2
- Name
- KIT proto-oncogene, receptor tyrosine kinase b
- Symbol
- kitb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within embryonic hemopoiesis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including gonad; immune system; nervous system; otic vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d836 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Mahony et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9136 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15348 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32649 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko370a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko370b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kitb | China Zebrafish Resource Center (CZRC) | |
| MO1-kitb | N/A | Mahony et al., 2018 |
| MO2-kitb | N/A | Mahony et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| gastrointestinal stromal tumor | Alliance | Gastrointestinal stromal tumor, familial | 606764 |
| mastocytosis | Alliance | Mastocytosis, cutaneous | 154800 |
| mastocytosis | Alliance | Mastocytosis, systemic, somatic | 154800 |
| piebaldism | Alliance | Piebaldism | 172800 |
| testicular germ cell cancer | Alliance | Germ cell tumors, somatic | 273300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR027263 | Mast/stem cell growth factor receptor |
| Family | IPR042495 | Platelet-derived growth factor receptor-like protein |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Mast/stem cell growth factor receptor | Platelet-derived growth factor receptor-like protein | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q4PKP5 | InterPro | 346 | ||||||||||||||||
| UniProtKB:A4JYS7 | InterPro | 205 | ||||||||||||||||
| UniProtKB:B8A5K6 | InterPro | 957 | ||||||||||||||||
| UniProtKB:Q5EGE5 | InterPro | 227 |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-245P14 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d836 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001143918 (1) | 2930 nt | ||
| Genomic | GenBank:BX548248 (1) | 195620 nt | ||
| Polypeptide | UniProtKB:B8A5K6 (1) | 957 aa |
- Tuttle, A.M., Miller, L.N., Royer, L.J., Wen, H., Kelly, J.J., Calistri, N.L., Heiser, L.M., Nechiporuk, A.V. (2024) Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(16):
- Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8
- Kim, D., Koun, S., Kim, S.Y., Ha, Y.R., Choe, J.W., Jung, S.W., Hyun, J.J., Jung, Y.K., Koo, J.S., Yim, H.J., Lee, S.W. (2021) Prokinetic effects of diatrizoate meglumine (Gastrografin®) in a zebrafish for opioid-induced constipation model. Animal cells and systems. 25:264-271
- Ma, H., Liu, Z., Yang, Y., Feng, D., Dong, Y., Garbutt, T.A., Hu, Z., Wang, L., Luan, C., Cooper, C.D., Li, Y., Welch, J.D., Qian, L., Liu, J. (2021) Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration. EMBO reports. 22(11):e52901
- Caetano-Lopes, J., Henke, K., Urso, K., Duryea, J., Charles, J.F., Warman, M.L., Harris, M.P. (2020) Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development (Cambridge, England). 147(2):
- Oltova, J., Svoboda, O., Machonova, O., Svatonova, P., Traver, D., Kolar, M., Bartunek, P. (2020) Zebrafish Kit ligands cooperate with erythropoietin to promote erythroid cell expansion. Blood advances. 4:5915-5924
- Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., Wang, C. (2020) Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems. Journal of hazardous materials. 404:124083
- Crespo, D., Assis, L.H.C., van de Kant, H.J.G., de Waard, S., Safian, D., Lemos, M.S., Bogerd, J., Schulz, R.W. (2019) Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-stimulating hormone, retinoic acid and androgens. Development (Cambridge, England). 146(21):
- Mahony, C.B., Pasche, C., Bertrand, J.Y. (2018) Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Stem Cell Reports. 10(6):1920-1934
- de Preux Charles, A.S., Bise, T., Baier, F., Marro, J., Jaźwińska, A. (2016) Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart. Open Biology. 6(7)
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