Gene

zgc:114200

ID

ZDB-GENE-050913-96

Name

zgc:114200

Symbol

zgc:114200 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in Notch receptor processing; Notch signaling pathway; and protein processing. Predicted to act upstream of or within positive regulation of catalytic activity. Predicted to be located in membrane. Predicted to be part of gamma-secretase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human APH1A (aph-1 homolog A, gamma-secretase subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa2562	Allele with one point mutation	Unknown	Splice Site	ENU

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Sequence Targeting Reagents

No data available

Human Disease

Associated With zgc:114200 Human Ortholog

No data available

Associated With zgc:114200 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR009294	Gamma-secretase subunit Aph-1

Domain Details Per Protein

Protein	Additional Resources	Length	Gamma-secretase subunit Aph-1
UniProtKB:Q4V8Q7	InterPro	253

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 10

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	zgc:114200-201 (1) Ensembl	Ensembl		10,806 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-30O2	CT573295	ZFIN Curated Data
Encodes	EST	fb81h04	AI545476 AI584666
Encodes	cDNA	MGC:114200	BC097248	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001030129 (1)	1779 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX005434 (1)	146695 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q4V8Q7 (1)	253 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

No data available

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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