Gene
pggt1b
- ID
- ZDB-GENE-050913-85
- Name
- protein geranylgeranyltransferase type I, beta subunit
- Symbol
- pggt1b Nomenclature History
- Previous Names
-
- ggt1b (1)
- zgc:114070
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable protein geranylgeranyltransferase activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity. Acts upstream of or within blood vessel maturation. Predicted to be part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:114070 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026580Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9024 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 2 of 2
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pggt1b | N/A | (2) |
| MO2-pggt1b | N/A | (2) |
| MO3-pggt1b | N/A | (2) |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001330 | Prenyltransferase alpha-alpha toroid domain |
| Family | IPR041960 | Geranylgeranyl transferase type-1 subunit beta |
| Family | IPR045089 | Prenyltransferase subunit beta |
| Homologous_superfamily | IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
1 - 4 of 4
Domain Details Per Protein
| Protein | Additional Resources | Length | Geranylgeranyl transferase type-1 subunit beta | Prenyltransferase alpha-alpha toroid domain | Prenyltransferase subunit beta | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
|---|---|---|---|---|---|---|
| UniProtKB:Q4V8Z9 | InterPro | 355 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pggt1b-201
(1)
|
Ensembl | 1,526 nt | ||
| ncRNA |
pggt1b-002
(1)
|
Ensembl | 725 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-299B15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114070 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030255 (1) | 1692 nt | ||
| Genomic | GenBank:FP017151 (1) | 27204 nt | ||
| Polypeptide | UniProtKB:Q4V8Z9 (1) | 355 aa |
- Hu, M., Veldman, M.B. (2025) Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway. Molecular neurodegeneration. 20:2828
- Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):
- El-Rass, S., Eisa-Beygi, S., Khong, E., Brand-Arzamendi, K., Mauro, A., Zhang, H., Clark, K.J., Ekker, S.C., Wen, X.Y. (2017) Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly.. Biology Open. 6(3):348-357
- Sullivan, C., Lage, C.R., Yoder, J.A., Postlethwait, J.H., Kim, C.H. (2017) Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. PLoS One. 12:e0179517
- Nishiya, N., Oku, Y., Kumagai, Y., Sato, Y., Yamaguchi, E., Sasaki, A., Shoji, M., Ohnishi, Y., Okamoto, H., Uehara, Y. (2014) A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/beta-catenin Pathway. Chemistry & Biology. 21:530-40
- Eisa-Beygi, S., Hatch, G., Noble, S., Ekker, M., and Moon, T.W. (2013) The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway. Developmental Biology. 373(2):258-266
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Mapp, O.M., Walsh, G.S., Moens, C.B., Tada, M., and Prince, V.E. (2011) Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Development (Cambridge, England). 138(10):2121-2132
- Cao, P., Hanai, J.I., Tanksale, P., Imamura, S., Sukhatme, V.P., and Lecker, S.H. (2009) Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(9):2844-2854
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 10 of 13
Show