Gene
dnm2a
- ID
- ZDB-GENE-050913-84
- Name
- dynamin 2a
- Symbol
- dnm2a Nomenclature History
- Previous Names
-
- dnm2
- zgc:114072
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within several processes, including chordate embryonic development; convergent extension; and somite development. Predicted to be active in several cellular components, including microtubule; plasma membrane; and synapse. Is expressed in several structures, including central nervous system; liver; otic vesicle; paraxial mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024273Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9093 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13248 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13768 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15133 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16501 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17720 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20128 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20129 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20130 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 10 of 10
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dnm2a | N/A | (3) |
| MO2-dnm2a | N/A | Gibbs et al., 2013 |
| MO3-dnm2a | N/A | Bragato et al., 2016 |
| MO4-dnm2a | N/A | Bragato et al., 2016 |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| centronuclear myopathy 1 | Alliance | Centronuclear myopathy 1 | 160150 |
| Charcot-Marie-Tooth disease dominant intermediate B | Alliance | Charcot-Marie-Tooth disease, axonal type 2M | 606482 |
| Charcot-Marie-Tooth disease dominant intermediate B | Alliance | Charcot-Marie-Tooth disease, dominant intermediate B | 606482 |
| Lethal congenital contracture syndrome 5 | 615368 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019762 | Dynamin, GTPase region, conserved site |
| Domain | IPR000375 | Dynamin stalk domain |
| Domain | IPR001401 | Dynamin, GTPase domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR003130 | Dynamin GTPase effector |
| Domain | IPR020850 | GTPase effector domain |
| Domain | IPR030381 | Dynamin-type guanine nucleotide-binding (G) domain |
| Domain | IPR045063 | Dynamin, N-terminal |
| Family | IPR022812 | Dynamin |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynamin | Dynamin, GTPase domain | Dynamin GTPase effector | Dynamin, GTPase region, conserved site | Dynamin, N-terminal | Dynamin stalk domain | Dynamin-type guanine nucleotide-binding (G) domain | GTPase effector domain | PH-like domain superfamily | Pleckstrin homology domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IIR1 | InterPro | 860 | |||||||||||
| UniProtKB:T1SXK0 | InterPro | 856 | |||||||||||
| UniProtKB:A0A8M9PW32 | InterPro | 860 | |||||||||||
| UniProtKB:A0A8M9P798 | InterPro | 867 | |||||||||||
| UniProtKB:A0A8M9PHU4 | InterPro | 856 | |||||||||||
| UniProtKB:Q4V8Z7 | InterPro | 755 | |||||||||||
| UniProtKB:A0A8M9PNW1 | InterPro | 878 | |||||||||||
| UniProtKB:A0A8M9PZL4 | InterPro | 874 | |||||||||||
| UniProtKB:A0A8M9PHT6 | InterPro | 885 | |||||||||||
| UniProtKB:A0AB32TBP4 | InterPro | 878 | |||||||||||
| UniProtKB:A0AB32TD14 | InterPro | 903 | |||||||||||
| UniProtKB:A0AB32TD82 | InterPro | 874 | |||||||||||
| UniProtKB:A0AB32TE56 | InterPro | 896 | |||||||||||
| UniProtKB:A0AB32TEM8 | InterPro | 878 | |||||||||||
| UniProtKB:A0AB32TH80 | InterPro | 845 | |||||||||||
| UniProtKB:A0AB32TIH4 | InterPro | 856 | |||||||||||
| UniProtKB:A0AB32TIR1 | InterPro | 892 |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.8ctbp2a:dnm2a-EGFP) |
|
| 1 | (2) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-286H12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114072 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030128 (1) | 2589 nt | ||
| Genomic | GenBank:BX088529 (2) | 178667 nt | ||
| Polypeptide | UniProtKB:A0AB32TD14 (1) | 903 aa |
- Aranda-Martínez, P., Sayed, R.K.A., Fernández-Martínez, J., Ramírez-Casas, Y., Yang, Y., Escames, G., Acuña-Castroviejo, D. (2024) Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. International Journal of Molecular Sciences. 25(11):
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Babu, N.S., Murthy, C.L., Kakara, S., Sharma, R., Swamy, C.V., Idris, M.M. (2016) MPTP induced Parkinson's disease in zebrafish. Proteomics. 16(9):1407-20
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Bragato, C., Gaudenzi, G., Blasevich, F., Pavesi, G., Maggi, L., Giunta, M., Cotelli, F., Mora, M. (2016) Zebrafish as a Model to Investigate Dynamin 2-Related Diseases. Scientific Reports. 6:20466
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Desvignes, T., Contreras, A., Postlethwait, J.H. (2014) Evolution of the miR199-214 cluster and vertebrate skeletal development. RNA Biology. 11(4):281-94
- Pelassa, I., Zhao, C., Pasche, M., Odermatt, B., Lagnado, L. (2014) Synaptic vesicles are "primed" for fast clathrin-mediated endocytosis at the ribbon synapse. Frontiers in molecular neuroscience. 7:91
1 - 10 of 18
Show