Gene
fbxo7
- ID
- ZDB-GENE-050913-68
- Name
- F-box protein 7
- Symbol
- fbxo7 Nomenclature History
- Previous Names
-
- si:ch211-286m4.2
- zgc:114096
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase binding activity. Involved in several processes, including dopaminergic neuron differentiation; larval locomotory behavior; and post-anal tail morphogenesis. Acts upstream of or within musculoskeletal movement. Located in cytoplasm and nucleus. Is expressed in brain; heart; and liver. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:114096 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Zhao et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1523 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fbxo7 | N/A | Zhao et al., 2012 |
| MO2-fbxo7 | N/A | Zhao et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Parkinson's disease 15 | Alliance | Parkinson disease 15, autosomal recessive | 260300 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | F-box domain | F-box-like domain superfamily | F-box only protein 7 | PI31 proteasome regulator, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PHA1 | InterPro | 485 | ||||
| UniProtKB:Q4V8X6 | InterPro | 486 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-4I5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-286M4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114096 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025499 (1) | 1743 nt | ||
| Genomic | GenBank:AL845512 | 192940 nt | ||
| Polypeptide | UniProtKB:Q4V8X6 (1) | 486 aa |
- Zhao, T., Zondervan-van der Linde, H., Severijnen, L.A., Oostra, B.A., Willemsen, R., and Bonifati, V. (2012) Dopaminergic neuronal loss and dopamine-dependent locomotor defects in fbxo7-deficient zebrafish. PLoS One. 7(11):e48911
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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