Gene

pacsin1b

ID

ZDB-GENE-050913-35

Name

protein kinase C and casein kinase substrate in neurons 1b

Symbol

pacsin1b Nomenclature History

Previous Names

pacsin1
fe25d06
syndapin I (1)
wu:fe25d06
zgc:114042

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable phospholipid binding activity. Acts upstream of or within auditory receptor cell stereocilium organization and cilium assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; cytosol; and ruffle membrane. Predicted to be active in endosome and plasma membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and presumptive neural retina. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pacsin1b Human Ortholog

No data available

Associated With pacsin1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001060	FCH domain
Domain	IPR001452	SH3 domain
Domain	IPR031160	F-BAR domain
Domain	IPR035743	PACSIN1/PACSIN2, SH3 domain
Domain	IPR037454	PACSIN1, F-BAR
Homologous_superfamily	IPR027267	AH/BAR domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	AH/BAR domain superfamily	F-BAR domain	FCH domain	PACSIN1, F-BAR	PACSIN1/PACSIN2, SH3 domain	SH3 domain	SH3-like domain superfamily
UniProtKB:B2GTA5	InterPro	445
UniProtKB:Q4V920	InterPro	445

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pacsin1b-201 (1) Ensembl	Ensembl	2,622 nt	Select Tool ZFIN BLAST
mRNA	pacsin1b-202 (1) Ensembl	Ensembl	2,663 nt	Select Tool ZFIN BLAST
mRNA	pacsin1b-203 (1) Ensembl	Ensembl	561 nt	Select Tool ZFIN BLAST
mRNA	pacsin1b-204 (1) Ensembl	Ensembl	1,352 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations