Gene
pacsin1b
- ID
- ZDB-GENE-050913-35
- Name
- protein kinase C and casein kinase substrate in neurons 1b
- Symbol
- pacsin1b Nomenclature History
- Previous Names
-
- pacsin1
- fe25d06
- syndapin I (1)
- wu:fe25d06
- zgc:114042
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable phospholipid binding activity. Acts upstream of or within auditory receptor cell stereocilium organization and cilium assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; cytosol; and ruffle membrane. Predicted to be active in endosome and plasma membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and presumptive neural retina. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | PACSIN1, F-BAR | PACSIN1/PACSIN2, SH3 domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B2GTA5 | InterPro | 445 | |||||||
| UniProtKB:Q4V920 | InterPro | 445 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pacsin1b-201
(1)
|
Ensembl | 2,622 nt | ||
| mRNA |
pacsin1b-202
(1)
|
Ensembl | 2,663 nt | ||
| mRNA |
pacsin1b-203
(1)
|
Ensembl | 561 nt | ||
| mRNA |
pacsin1b-204
(1)
|
Ensembl | 1,352 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-135I4 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-194M6 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-333H4 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-1862H6 | ZFIN Curated Data | |
| Encodes | EST | fe25d06 | ||
| Encodes | cDNA | MGC:114042 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192905 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001033728 (1) | 2651 nt | ||
| Genomic | GenBank:CU694224 (1) | 115102 nt | ||
| Polypeptide | UniProtKB:B2GTA5 (1) | 445 aa |
- Morgan, J., Yarwood, R., Starborg, T., Yan, G., Lowe, M. (2022) Pacsin2 is required for endocytosis in the zebrafish pronephric tubule. Biology Open. 11(6):
- Insinna, C., Lu, Q., Teixeira, I., Harned, A., Semler, E.M., Stauffer, J., Magidson, V., Tiwari, A., Kenworthy, A.K., Narayan, K., Westlake, C.J. (2019) Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. Nature communications. 10:428
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Schuler, S., Hauptmann, J., Perner, B., Kessels, M.M., Englert, C., and Qualmann, B. (2013) Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. Journal of Cell Science. 126(1):196-208
- Edeling, M.A., Sanker, S., Shima, T., Umasankar, P.K., Höning, S., Kim, H.Y., Davidson, L.A., Watkins, S.C., Tsang, M., Owen, D.J., and Traub, L.M. (2009) Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One. 4(12):e8150
- Eckfeldt, C.E., Mendenhall, E.M., Flynn, C.M., Wang, T.F., Pickart, M.A., Grindle, S.M., Ekker, S.C., and Verfaillie, C.M. (2005) Functional analysis of human hematopoietic stem cell gene expression using zebrafish. PLoS Biology. 3(8):e254
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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