Gene

il10rb

ID

ZDB-GENE-050909-1

Name

interleukin 10 receptor, beta

Symbol

il10rb Nomenclature History

Previous Names

IL10R2 (1)
il10rbl
crfb5
zgc:153823

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Exhibits interferon receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in hepatitis B; hepatitis C; and inflammatory bowel disease 25. Is expressed in head and heart. Orthologous to several human genes including IFNAR1 (interferon alpha and beta receptor subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Phenotype Annotation (1994-2006)
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il10rb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
inflammatory bowel disease 25	Alliance	Inflammatory bowel disease 25, early onset, autosomal recessive	612567
		{Hepatitis B virus, susceptibility to}	610424

Associated With il10rb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Domain	IPR015373	Interferon/interleukin receptor domain
Family	IPR050650	Type II Cytokine and Tissue Factor Receptors
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily