Gene
il10rb
- ID
- ZDB-GENE-050909-1
- Name
- interleukin 10 receptor, beta
- Symbol
- il10rb Nomenclature History
- Previous Names
-
- IL10R2 (1)
- il10rbl
- crfb5
- zgc:153823
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables interferon receptor activity. Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head; heart; and intestine. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; hepatitis C; inflammatory bowel disease 25; and primary immunodeficiency disease. Orthologous to several human genes including IL10RB (interleukin 10 receptor subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Phenotype Annotation (1994-2006)
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| inflammatory bowel disease 25 | Alliance | Inflammatory bowel disease 25, early onset, autosomal recessive | 612567 |
| {Hepatitis B virus, susceptibility to} | 610424 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR015373 | Interferon/interleukin receptor domain |
| Family | IPR050650 | Type II Cytokine and Tissue Factor Receptors |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Interferon/interleukin receptor domain | Type II Cytokine and Tissue Factor Receptors |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N7Q2 | InterPro | 367 | |||||
| UniProtKB:A0A8M9QJT9 | InterPro | 310 | |||||
| UniProtKB:A0A8M9QAX8 | InterPro | 366 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
il10rb-201
(1)
|
Ensembl | 594 nt | ||
| mRNA |
il10rb-202
(1)
|
Ensembl | 1,676 nt |
Interactions and Pathways
No data available
Plasmids
No data available