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ZIRC
ZFIN ID: ZDB-GENE-050816-1
Gene Name: tyrosyl-DNA phosphodiesterase 2b
Gene Symbol: tdp2b
Sequence Ontology ID : SO:0000704

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Previous Names: tdp2, ttrap, ttrapl

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(Including Attributions)
Location: Chr: 19 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits DNA binding activity and tyrosyl-DNA phosphodiesterase activity. Involved in convergent extension involved in gastrulation; determination of left/right symmetry; and negative regulation of  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7157406]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010924Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH tdp2b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Spinocerebellar ataxia, autosomal recessive 23 616949
    Spinocerebellar ataxia, autosomal recessive 23 616949
    DISEASE ASSOCIATED WITH tdp2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component PML body (more)
    Molecular Function DNA binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR005135 (1)
  • InterPro:IPR009060 (1)
  • InterPro:IPR036691 (1)
  • Pfam:PF03372 (1)
  • EC:3.1.4.- (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tdp2b-201 (1) 1727
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tdp2b No data available
    MARKER RELATIONSHIPS
    tdp2bContained in: [BAC] DKEY-218N20 (1) (order this)
    tdp2bEncodes: [EST] IMAGE:7157406 (1) (order this)
    [cDNA] MGC:136306 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001079703 (1) 1451bp
    Genomic GenBank:BX957279 (1) 198752bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IPL5 (1) 396aa
    Sequence Clusters UniGene:18071 (1)
    Sequence Information (all 25)
    ORTHOLOGY for tdp2b (Chr: 19)
    CITATIONS (28)