Gene
tdp2b
- ID
- ZDB-GENE-050816-1
- Name
- tyrosyl-DNA phosphodiesterase 2b
- Symbol
- tdp2b Nomenclature History
- Previous Names
-
- tdp2
- ttrap
- ttrapl
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables DNA binding activity and tyrosyl-DNA phosphodiesterase activity. Involved in determination of left/right symmetry and gastrulation. Acts upstream of or within convergent extension involved in gastrulation and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in nucleus. Predicted to be active in PML body and cytoplasm. Is expressed in Kupffer's vesicle; forerunner cell group; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 23. Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157406 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Esguerra et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 23 | Alliance | Spinocerebellar ataxia, autosomal recessive 23 | 616949 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Endonuclease/exonuclease/phosphatase | Endonuclease/exonuclease/phosphatase superfamily | Tyrosyl-DNA phosphodiesterase 2-like | UBA-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q5XJA0
|
369 |
Interactions and Pathways
No data available
Plasmids