ZFIN is now using GRCz12tu for Genomic Data
Gene
magi2a
- ID
- ZDB-GENE-050810-4
- Name
- membrane associated guanylate kinase, WW and PDZ domain containing 2a
- Symbol
- magi2a Nomenclature History
- Previous Names
-
- magi2
- fb82g11
- si:dkey-97c7.1 (1)
- si:dkeyp-86a5.1
- wu:fb82g11
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within pronephric glomerulus development. Predicted to be located in several cellular components, including centriole; photoreceptor inner segment; and photoreceptor outer segment. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Is expressed in pronephric glomerulus. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Dong et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 15 | Alliance | Nephrotic syndrome, type 15 | 617609 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001202 | WW domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR041489 | PDZ domain 6 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
magi2a-201
(1)
|
Ensembl | 7,499 nt | ||
| mRNA |
magi2a-202
(1)
|
Ensembl | 3,825 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers