ZFIN is now using GRCz12tu for Genomic Data
Gene
trrap
- ID
- ZDB-GENE-050809-47
- Name
- transformation/transcription domain-associated protein
- Symbol
- trrap Nomenclature History
- Previous Names
-
- fc54d09
- im:7154030
- wu:fc54d09
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein kinase activity. Involved in neuromast hair cell development and startle response. Acts upstream of or within cartilage morphogenesis and regulation of odontogenesis. Predicted to be part of NuA4 histone acetyltransferase complex and SAGA complex. Predicted to be active in nucleus. Is expressed in head. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154030 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 75 | Alliance | ?Deafness, autosomal dominant 75 | 618778 |
| Developmental delay with or without dysmorphic facies and autism | 618454 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness | trrapzf3166/+ | standard conditions | Xia et al., 2019 |
| autosomal dominant nonsyndromic deafness | AB + MO2-trrap | standard conditions | Xia et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR003151 | PIK-related kinase, FAT |
| Domain | IPR003152 | FATC domain |
| Domain | IPR014009 | PIK-related kinase |
| Family | IPR050517 | DNA Damage Response and Repair Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Repeat | IPR046805 | Tra1, HEAT repeat ring region |
| Repeat | IPR046807 | Tra1, HEAT repeat central region |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | DNA Damage Response and Repair Kinase | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Tra1, HEAT repeat central region | Tra1, HEAT repeat ring region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B4M5 | InterPro | 3839 | ||||||||||
| UniProtKB:A0A8M9PMB6 | InterPro | 1273 | ||||||||||
| UniProtKB:A0A0R4IPE4 | InterPro | 3834 | ||||||||||
| UniProtKB:A0A0R4ITC5 | InterPro | 3841 | ||||||||||
| UniProtKB:A0AB13ABF5 | InterPro | 3839 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers