Gene
trrap
- ID
- ZDB-GENE-050809-47
- Name
- transformation/transcription domain-associated protein
- Symbol
- trrap Nomenclature History
- Previous Names
-
- fc54d09
- im:7154030
- wu:fc54d09
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have transcription coregulator activity. Involved in neuromast hair cell development. Predicted to localize to NuA4 histone acetyltransferase complex and SAGA complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human TRRAP (transformation/transcription domain associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154030 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
autosomal dominant nonsyndromic deafness | trrapzf3166/+ | standard conditions | Xia et al., 2019 |
autosomal dominant nonsyndromic deafness | AB + MO2-trrap | standard conditions | Xia et al., 2019 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
Domain | IPR003151 | PIK-related kinase, FAT |
Domain | IPR003152 | FATC domain |
Domain | IPR014009 | PIK-related kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR011989 | Armadillo-like helical |
Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
Homologous_superfamily | IPR016024 | Armadillo-type fold |
Repeat | IPR046805 | Tra1, HEAT repeat ring region |
Repeat | IPR046807 | Tra1, HEAT repeat central region |
Domain Details Per Protein
Protein | Length | Armadillo-like helical | Armadillo-type fold | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Tetratricopeptide-like helical domain superfamily | Tra1, HEAT repeat central region | Tra1, HEAT repeat ring region |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3B4M5
|
3839 | ||||||||||
UniProtKB:A0A8M9PMB6
|
1273 | ||||||||||
UniProtKB:A0A0R4IPE4
|
3834 | ||||||||||
UniProtKB:A0A0R4ITC5
|
3841 |
Interactions and Pathways
No data available
Plasmids
No data available