Gene
trrap
- ID
- ZDB-GENE-050809-47
- Name
- transformation/transcription domain-associated protein
- Symbol
- trrap Nomenclature History
- Previous Names
-
- fc54d09
- im:7154030
- wu:fc54d09
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have transcription coregulator activity. Predicted to be involved in DNA repair and regulation of transcription, DNA-templated. Predicted to localize to NuA4 histone acetyltransferase complex and SAGA complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human TRRAP (transformation/transcription domain associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154030 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 75 | Alliance | ?Deafness, autosomal dominant 75 | 618778 |
| Developmental delay with or without dysmorphic facies and autism | 618454 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness | trrapzf3166/+ | standard conditions | Xia et al., 2019 |
| autosomal dominant nonsyndromic deafness | AB + MO2-trrap | standard conditions | Xia et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR003151 | PIK-related kinase, FAT |
| Domain | IPR003152 | FATC domain |
| Domain | IPR014009 | PIK-related kinase |
| Family | IPR050517 | DNA Damage Response and Repair Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Repeat | IPR046805 | Tra1, HEAT repeat ring region |
| Repeat | IPR046807 | Tra1, HEAT repeat central region |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | DNA Damage Response and Repair Kinase | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Tetratricopeptide-like helical domain superfamily | Tra1, HEAT repeat central region | Tra1, HEAT repeat ring region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B4M5
|
3839 | |||||||||||
|
UniProtKB:A0A8M9PMB6
|
1273 | |||||||||||
|
UniProtKB:A0A0R4IPE4
|
3834 | |||||||||||
|
UniProtKB:A0A0R4ITC5
|
3841 |
Interactions and Pathways
No data available
Plasmids
No data available