Gene

trrap

ID

ZDB-GENE-050809-47

Name

transformation/transcription domain-associated protein

Symbol

trrap Nomenclature History

Previous Names

fc54d09
im:7154030
wu:fc54d09

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable kinase activity. Involved in neuromast hair cell development and startle response. Predicted to be part of NuA4 histone acetyltransferase complex and SAGA complex. Predicted to be active in nucleus. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7154030 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trrap Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 75	Alliance	?Deafness, autosomal dominant 75	618778
		Developmental delay with or without dysmorphic facies and autism	618454

Associated With trrap Via Experimental Models

Human Disease	Fish	Conditions	Citations
autosomal dominant nonsyndromic deafness	trrap^zf3166/+	standard conditions	Xia et al., 2019
autosomal dominant nonsyndromic deafness	AB + MO2-trrap	standard conditions	Xia et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR003151	PIK-related kinase, FAT
Domain	IPR003152	FATC domain
Domain	IPR014009	PIK-related kinase
Family	IPR050517	DNA Damage Response and Repair Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR046805	Tra1, HEAT repeat ring region
Repeat	IPR046807	Tra1, HEAT repeat central region

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	DNA Damage Response and Repair Kinase	FATC domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	PIK-related kinase	PIK-related kinase, FAT	Protein kinase-like domain superfamily	Tetratricopeptide-like helical domain superfamily	Tra1, HEAT repeat central region	Tra1, HEAT repeat ring region
UniProtKB:A0A8M3B4M5 InterPro	3839
UniProtKB:A0A8M9PMB6 InterPro	1273
UniProtKB:A0A0R4IPE4 InterPro	3834
UniProtKB:A0A0R4ITC5 InterPro	3841

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	trrap-201 (1) Ensembl	Ensembl	11,526 nt	Select Tool ZFIN BLAST
mRNA	trrap-203 (1) Ensembl	Ensembl	12,591 nt	Select Tool ZFIN BLAST
mRNA	trrap-204 (1) Ensembl	Ensembl	11,505 nt	Select Tool ZFIN BLAST
ncRNA	trrap-002 (1) Ensembl	Ensembl	972 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations