Gene

iqgap1

ID
ZDB-GENE-050809-24
Name
IQ motif containing GTPase activating protein 1
Symbol
iqgap1 Nomenclature History
Previous Names
  • im:7152854
  • im:7156663
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to act upstream of or within regulation of GTPase activity and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; ectoderm; gut; perichondrium; and pharyngeal arch. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With iqgap1 Human Ortholog
No data available
Associated With iqgap1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Conserved_site IPR023152 Ras GTPase-activating protein, conserved site
Domain IPR000593 RasGAP protein, C-terminal
Domain IPR001202 WW domain
Domain IPR001715 Calponin homology domain
Domain IPR001936 Ras GTPase-activating domain
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036872 CH domain superfamily
Domain Details Per Protein
Protein Length Calponin homology domain CH domain superfamily IQ motif, EF-hand binding site P-loop containing nucleoside triphosphate hydrolase RasGAP protein, C-terminal Ras GTPase-activating domain Ras GTPase-activating protein, conserved site Rho GTPase activation protein WW domain
UniProtKB:A0A0F7C9F3 1655
UniProtKB:E7FBD5 1655
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations