Gene

iqgap1

ID

ZDB-GENE-050809-24

Name

IQ motif containing GTPase activating protein 1

Symbol

iqgap1 Nomenclature History

Previous Names

im:7152854
im:7156663

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to act upstream of or within regulation of GTPase activity and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; ectoderm; gut; perichondrium; and pharyngeal arch. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7152854 (1 image)
IMAGE:7156663 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iqgap1 Human Ortholog

No data available

Associated With iqgap1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Conserved_site	IPR023152	Ras GTPase-activating protein, conserved site
Domain	IPR000593	RasGAP protein, C-terminal
Domain	IPR001202	WW domain
Domain	IPR001715	Calponin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036872	CH domain superfamily