Gene
pora
- ID
- ZDB-GENE-050809-121
- Name
- P450 (cytochrome) oxidoreductase a
- Symbol
- pora Nomenclature History
- Previous Names
-
- por
- zgc:110032
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have NADPH-hemoprotein reductase activity; coenzyme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in response to hormone. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome and congenital adrenal hyperplasia. Orthologous to human POR (cytochrome p450 oxidoreductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu599 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Antley-Bixler syndrome with disordered steroidogenesis | Alliance | Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis | 201750 |
| cytochrome P450 oxidoreductase deficiency | Alliance | Disordered steroidogenesis due to cytochrome P450 oxidoreductase | 613571 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001094 | Flavodoxin-like |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR001709 | Flavoprotein pyridine nucleotide cytochrome reductase |
| Domain | IPR003097 | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
| Domain | IPR008254 | Flavodoxin/nitric oxide synthase |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Family | IPR023208 | NADPH-cytochrome P450 reductase |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR023173 | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily |
| Homologous_superfamily | IPR029039 | Flavoprotein-like superfamily |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
| Protein | Length | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavodoxin-like | Flavodoxin/nitric oxide synthase | Flavoprotein-like superfamily | Flavoprotein pyridine nucleotide cytochrome reductase | NADPH-cytochrome P450 reductase | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q499B1
|
674 | |||||||||||
|
UniProtKB:A0A8M2BKF9
|
634 |
Interactions and Pathways
No data available
Plasmids
No data available