Gene

nsun3

ID

ZDB-GENE-050706-95

Name

NOP2/Sun RNA methyltransferase 3

Symbol

nsun3 Nomenclature History

Previous Names

im:7142194
zgc:109983

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable tRNA (cytosine-5-)-methyltransferase activity. Predicted to be involved in rRNA methylation; regulation of mitochondrial translation; and tRNA wobble base cytosine methylation. Predicted to act upstream of or within RNA methylation. Predicted to be located in mitochondrial matrix. Predicted to be part of mitochondrial large ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 48. Orthologous to human NSUN3 (NOP2/Sun RNA methyltransferase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nsun3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 48	Alliance	Combined oxidative phosphorylation deficiency 48	619012

Associated With nsun3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001678	SAM-dependent methyltransferase RsmB-F/NOP2-type domain
Domain	IPR049560	SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core
Family	IPR023267	RNA (C5-cytosine) methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily