Gene
isca1
- ID
- ZDB-GENE-050626-94
- Name
- iron-sulfur cluster assembly 1
- Symbol
- isca1 Nomenclature History
- Previous Names
-
- magr (1)
- zgc:114185
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have 2 iron, 2 sulfur cluster binding activity. Involved in heme biosynthetic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nilsson et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple mitochondrial dysfunctions syndrome 5 | Alliance | Multiple mitochondrial dysfunctions syndrome 5 | 617613 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017870 | FeS cluster insertion, C-terminal, conserved site |
| Domain | IPR000361 | FeS cluster biogenesis |
| Family | IPR016092 | FeS cluster insertion protein |
| Family | IPR050322 | Iron-sulfur cluster assembly and transfer HesB/IscA |
| Homologous_superfamily | IPR035903 | HesB-like domain superfamily |
Domain Details Per Protein
| Protein | Length | FeS cluster biogenesis | FeS cluster insertion, C-terminal, conserved site | FeS cluster insertion protein | HesB-like domain superfamily | Iron-sulfur cluster assembly and transfer HesB/IscA |
|---|---|---|---|---|---|---|
|
UniProtKB:Q4QRC6
|
129 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available