Gene
ctss2.2
- ID
- ZDB-GENE-050626-55
- Name
- cathepsin S, ortholog 2, tandem duplicate 2
- Symbol
- ctss2.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Is expressed in blood; macrophage; and yolk syncytial layer. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112489 (11 images)
- MGC:111950 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q566T8
|
330 | ||||||||
|
UniProtKB:A0A8M3ATF0
|
337 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctss2.2-201
(1)
|
Ensembl | 1,267 nt | ||
| mRNA |
ctss2.2-203
(1)
|
Ensembl | 998 nt | ||
| ncRNA |
ctss2.2-002
(1)
|
Ensembl | 615 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- This gene and ctssb.1 (ZDB-GENE-050522-559) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human CTSS and mouse Ctss based on amino acid identity and conserved location.