Gene
angptl2b
- ID
- ZDB-GENE-050624-1
- Name
- angiopoietin-like 2b
- Symbol
- angptl2b Nomenclature History
- Previous Names
-
- angptl2
- wu:fc41g02
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within angiogenesis; hemopoiesis; and positive regulation of Notch signaling pathway. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including fin; gill; liver; spleen; and yolk. Orthologous to human ANGPTL2 (angiopoietin like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029474Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9722 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34443 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-angptl2b | N/A | (2) |
| MO2-angptl2b | N/A | Lin et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR050373 | Fibrinogen C-terminal domain-containing protein |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen, conserved site | Fibrinogen C-terminal domain-containing protein | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q5KQT9
|
510 | |||||
|
UniProtKB:B0UXH5
|
519 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
angptl2b-201
(1)
|
Ensembl | 3,472 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:angptl2b) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-281H24 | ZFIN Curated Data | |
| Encodes | EST | fc41g02 | ||
| Encodes | cDNA | MGC:194321 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194334 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126478 (1) | 3472 nt | ||
| Genomic | GenBank:CR361562 (2) | 160720 nt | ||
| Polypeptide | UniProtKB:B0UXH5 (1) | 519 aa |
- Shi, W.J., Jiang, Y.X., Huang, G.Y., Zhao, J.L., Zhang, J.N., Liu, Y.S., Xie, L., Ying, G.G. (2018) Dydrogesterone causes male bias and accelerates sperm maturation in zebrafish (Danio rerio). Environmental science & technology. 52(15):8903-8911
- Crippa, S., Nemir, M., Ounzain, S., Ibberson, M., Berthonneche, C., Sarre, A., Boisset, G., Maison, D., Harshman, K., Xenarios, I., Diviani, D., Schorderet, D., Pedrazzini, T. (2016) Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Cardiovascular research. 110(1):73-84
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lin, M.I., Price, E.N., Boatman, S., Hagedorn, E.J., Trompouki, E., Satishchandran, S., Carspecken, C.W., Uong, A., DiBiase, A., Yang, S., Canver, M.C., Dahlberg, A., Lu, Z., Zhang, C.C., Orkin, S.H., Bernstein, I.D., Aster, J.C., White, R.M., Zon, L.I. (2015) Angiopoietin-like proteins stimulate HSPC development through interaction with Notch receptor signaling. eLIFE. 4
- Lima, A., Cha, B.J., Amin, J., Smith, L.K., Anderson, B. (2014) Zebrafish Embryo Model of Bartonella Henselae Infection. Zebrafish. 11(5):434-46
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Lyman Gingerich, J., Lindeman, R., Putiri, E., Stolzmann, K., and Pelegri, F. (2006) Analysis of axis induction mutant embryos reveals morphogenetic events associated with zebrafish yolk extension formation. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(10):2749-2760
- Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Nagai, N., Koh, G.Y., Watanabe, S., and Suda, T. (2005) Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development. Proceedings of the National Academy of Sciences of the United States of America. 102(38):13502-13507
- Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Watanabe, S., and Suda, T. (2005) Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish. Gene expression patterns : GEP. 5(5):679-685
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