Gene
cyp3a65
- ID
- ZDB-GENE-050604-1
- Name
- cytochrome P450, family 3, subfamily A, polypeptide 65
- Symbol
- cyp3a65 Nomenclature History
- Previous Names
-
- zgc:123110
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable steroid hydroxylase activity. Acts upstream of or within response to xenobiotic stimulus. Predicted to be located in membrane. Is expressed in several structures, including digestive system; eye; gill; heart; and ovary. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A5 (cytochrome P450 family 3 subfamily A member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450 3A | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q32LT1 | InterPro | 517 | |||||
| UniProtKB:A0A8M1N818 | InterPro | 517 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp3a65-201
(1)
|
Ensembl | 2,020 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Han, S.C., Huang, R.P., Zhang, Q.Y., Yan, C.Y., Li, X.Y., Li, Y.F., He, R.R., Li, W.X. (2023) Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models. Foods (Basel, Switzerland). 12(5):
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Wang, S., Bao, J., Li, J., Li, W., Tian, M., Qiu, C., Pang, F., Li, X., Yang, J., Hu, Y., Wang, S., Jin, H. (2022) Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway. Molecules. 27(9):
- Zhao, X., Huang, X., Peng, W., Han, M., Zhang, X., Zhu, K., Shao, B. (2022) Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish. Ecotoxicology and environmental safety. 238:113568
- Duan, X.Y., Ma, R.J., Hsiao, C.D., Jiang, Z.Z., Zhang, L.Y., Zhang, Y., Liu, K.C. (2021) Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish. Chinese Journal of Natural Medicines. 19:750-757
- Lovin, L.M., Kim, S., Taylor, R.B., Scarlett, K.R., Langan, L.M., Chambliss, C.K., Chatterjee, S., Scott, J.T., Brooks, B.W. (2021) Differential influences of (±) anatoxin-a on photolocomotor behavior and gene transcription in larval zebrafish and fathead minnows. Environmental sciences Europe. 33(1):
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