Gene

myh11a

ID

ZDB-GENE-050531-1

Name

myosin, heavy chain 11a, smooth muscle

Symbol

myh11a Nomenclature History

Previous Names

myh11
meltdown
mlt
smmhc (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including digestive tract morphogenesis; heart contraction; and regulation of polarized epithelial cell differentiation. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in gut and muscle. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myh11a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
thoracic aortic aneurysm	Alliance	Aortic aneurysm, familial thoracic 4	132900
		Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	619351
		Visceral myopathy 2	619350

Associated With myh11a Via Experimental Models

Human Disease	Fish	Conditions	Citations
megacystis-microcolon-intestinal hypoperistalsis syndrome	myh11a^m498/+; myh11a^p318/+	standard conditions	Abrams et al., 2016
megacystis-microcolon-intestinal hypoperistalsis syndrome	myh11a^m498/+; myh11a^p319/+	standard conditions	Abrams et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002928	Myosin tail
Domain	IPR004009	Myosin, N-terminal, SH3-like
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily