Gene
hs6st1a
- ID
- ZDB-GENE-050524-1
- Name
- heparan sulfate 6-O-sulfotransferase 1a
- Symbol
- hs6st1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables heparan sulfate 6-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process. Predicted to act upstream of or within DNA integration and proteolysis. Predicted to be located in membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; neural tube; and polster. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110038 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 15 with or without anosmia | Alliance | {Hypogonadotropic hypogonadism 15 with or without anosmia} | 614880 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001969 | Aspartic peptidase, active site |
| Domain | IPR000477 | Reverse transcriptase domain |
| Domain | IPR001584 | Integrase, catalytic core |
| Domain | IPR003309 | SCAN domain |
| Domain | IPR018061 | Retropepsins |
| Domain | IPR041373 | Reverse transcriptase, RNase H-like domain |
| Domain | IPR041588 | Integrase zinc-binding domain |
| Domain | IPR054465 | Integrase p58-like, C-terminal domain |
| Family | IPR005331 | Sulfotransferase |
| Family | IPR010635 | Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase |
| Family | IPR050951 | Retrovirus-related Pol polyprotein |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR021109 | Aspartic peptidase domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
| Homologous_superfamily | IPR038269 | SCAN domain superfamily |
| Homologous_superfamily | IPR043128 | Reverse transcriptase/Diguanylate cyclase domain |
| Homologous_superfamily | IPR043502 | DNA/RNA polymerase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | DNA/RNA polymerase superfamily | Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase | Integrase, catalytic core | Integrase p58-like, C-terminal domain | Integrase zinc-binding domain | P-loop containing nucleoside triphosphate hydrolase | Retropepsins | Retrovirus-related Pol polyprotein | Reverse transcriptase/Diguanylate cyclase domain | Reverse transcriptase domain | Reverse transcriptase, RNase H-like domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily | SCAN domain | SCAN domain superfamily | Sulfotransferase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q56UJ5 | InterPro | 413 | ||||||||||||||||||
| UniProtKB:A0AB13ABZ8 | InterPro | 413 | ||||||||||||||||||
| UniProtKB:A0AB32TZX1 | InterPro | 1354 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hs6st1a-201
(1)
|
Ensembl | 737 nt | ||
| mRNA |
hs6st1a-202
(1)
|
Ensembl | 1,242 nt |
Interactions and Pathways
No data available
Plasmids
No data available