Gene
phlda2
- ID
- ZDB-GENE-050522-73
- Name
- pleckstrin homology-like domain, family A, member 2
- Symbol
- phlda2 Nomenclature History
- Previous Names
-
- zgc:110459
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm and membrane. Is expressed in several structures, including heart rudiment; intermediate cell mass of mesoderm; mesoderm; pectoral fin; and sensory system. Orthologous to human PHLDA2 (pleckstrin homology like domain family A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110459 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PHLDA family | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|
|
UniProtKB:Q503L1
|
136 | |||
|
UniProtKB:B2GSF6
|
136 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
phlda2-201
(1)
|
Ensembl | 920 nt | ||
| mRNA |
phlda2-202
(1)
|
Ensembl | 1,076 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-193F12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110459 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174286 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192589 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020596 (1) | 913 nt | ||
| Genomic | GenBank:CU024870 (2) | 116393 nt | ||
| Polypeptide | UniProtKB:B2GSF6 (1) | 136 aa |
- Gangras, P., Gallagher, T.L., Parthun, M.A., Yi, Z., Patton, R.D., Tietz, K.T., Deans, N.C., Bundschuh, R., Amacher, S.L., Singh, G. (2020) Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets. PLoS Genetics. 16:e1008830
- Sun, S., Li, X., Liu, Z., Zhang, G., Yang, C., Jiang, Q., Zou, Y. (2019) Expression of nucleosome assembly protein 1 like genes in zebrafish embryos. Gene expression patterns : GEP. 35:119076
- Boyle Anderson, E.A.T., Ho, R.K. (2018) A transcriptomics analysis of the Tbx5 paralogues in zebrafish. PLoS One. 13:e0208766
- Xu, H., Liu, X., Jia, Y., Dong, F., Xu, J., Wu, X., Yang, Y., Zheng, Y. (2018) Fipronil-induced toxic effects in zebrafish (Danio rerio) larvae by using digital gene expression profiling. The Science of the total environment. 639:550-559
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- Melvin, V.S., Feng, W., Hernandez-Lagunas, L., Artinger, K.B., and Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(7):817-31
- Taylor, A.M., Humphries, J.M., White, R.M., Murphey, R.D., Burns, C.E., and Zon, L.I. (2012) Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Experimental hematology. 40(3):228-237
- Yoshinari, N., Ishida, T., Kudo, A., and Kawakami, A. (2009) Gene expression and functional analysis of zebrafish larval fin fold regeneration. Developmental Biology. 325(1):71-81
- Leung, Y.F., Ma, P., and Dowling, J.E. (2007) Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Investigative ophthalmology & visual science. 48(2):881-890
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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