Gene

lims2

ID

ZDB-GENE-050522-56

Name

LIM and senescent cell antigen-like domains 2

Symbol

lims2 Nomenclature History

Previous Names

hm:zeh0381 (1)
pinch2 (1)
zeh0381
zgc:112257

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Involved in heart contraction and regulation of protein kinase B signaling. Predicted to localize to cell-cell junction; cytoplasm; and focal adhesion. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Is expressed in adaxial cell; myotome; pectoral fin musculature; and somite. Orthologous to several human genes including LIMS1 (LIM zinc finger domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112257 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Meder et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lims2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 2W	Alliance	?Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue	616827

Associated With lims2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001781	Zinc finger, LIM-type
Domain	IPR047944	LIMS1/2-like, LIM domain 1
Family	IPR047946	LIM and senescent cell antigen-like-containing domain protein 1/2-like