ZFIN is now using GRCz12tu for Genomic Data
Gene
trmu
- ID
- ZDB-GENE-050522-540
- Name
- tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
- Symbol
- trmu Nomenclature History
- Previous Names
-
- mut1 (1)
- zgc:110555
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable tRNA-5-taurinomethyluridine 2-sulfurtransferase activity. Predicted to be involved in mitochondrial tRNA wobble position uridine thiolation. Predicted to act upstream of or within tRNA processing. Predicted to be active in mitochondrion. Is expressed in several structures, including blastoderm; blastodisc; gut; sensory system; and swim bladder. Used to study inner ear disease. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Zhang et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aminoglycoside-induced deafness | Alliance | {Deafness, mitochondrial, modifier of} | 580000 |
| transient infantile liver failure | Alliance | Liver failure, transient infantile | 613070 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| inner ear disease | trmuzf3047/zf3047 | standard conditions | Zhang et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR046884 | tRNA-specific 2-thiouridylase MnmA-like, central domain |
| Domain | IPR046885 | tRNA-specific 2-thiouridylase MnmA-like, C-terminal domain |
| Family | IPR004506 | tRNA-specific 2-thiouridylase MnmA-like |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR023382 | tRNA-specific 2-thiouridylase MnmA-like, central domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Rossmann-like alpha/beta/alpha sandwich fold | tRNA-specific 2-thiouridylase MnmA-like | tRNA-specific 2-thiouridylase MnmA-like, central domain | tRNA-specific 2-thiouridylase MnmA-like, central domain superfamily | tRNA-specific 2-thiouridylase MnmA-like, C-terminal domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:B2GPX5 | InterPro | 416 | |||||
| UniProtKB:Q503J2 | InterPro | 416 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers