Gene

trmu

ID
ZDB-GENE-050522-540
Name
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Symbol
trmu Nomenclature History
Previous Names
  • mut1 (1)
  • zgc:110555
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; sulfurtransferase activity; and tRNA binding activity. Involved in mitochondrial tRNA thio-modification. Predicted to localize to mitochondrion. Is expressed in several structures, including blastoderm; blastodisc; gut; sensory system; and swim bladder. Used to study inner ear disease. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zhang et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Zhang et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With trmu Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aminoglycoside-induced deafness Alliance {Deafness, mitochondrial, modifier of} 580000
transient infantile liver failure Alliance Liver failure, transient infantile 613070
Associated With trmu Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR004506 tRNA-specific 2-thiouridylase
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR023382 Adenine nucleotide alpha hydrolase-like domains
Domain Details Per Protein
Protein Length Adenine nucleotide alpha hydrolase-like domains Rossmann-like alpha/beta/alpha sandwich fold tRNA-specific 2-thiouridylase
UniProtKB:Q503J2 416
UniProtKB:B2GPX5 416
UniProtKB:F1QRX8 416
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations