Gene
chtf18
- ID
- ZDB-GENE-050522-508
- Name
- CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
- Symbol
- chtf18 Nomenclature History
- Previous Names
-
- zgc:113153 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; eye; immature eye; optic tectum; and pharyngeal arch. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7161768 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa5934 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11678 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18673 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19429 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38244 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38245 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39550 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-chtf18 | Thomas et al., 2014 | |
| CRISPR2-chtf18 | Thomas et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ATPase, AAA-type, core | CTF18-RFC complex component | P-loop containing nucleoside triphosphate hydrolase | Replication factor C, lid domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QF60 | InterPro | 957 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chtf18-201
(1)
|
Ensembl | 3,240 nt | ||
| mRNA |
chtf18-203
(1)
|
Ensembl | 1,051 nt | ||
| ncRNA |
chtf18-002
(1)
|
Ensembl | 742 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-14K19 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-57D7 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7161768 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113153 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173632 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192547 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110102 (1) | 3230 nt | ||
| Genomic | GenBank:BX004779 (1) | 196036 nt | ||
| Polypeptide | UniProtKB:F1QF60 (1) | 957 aa |
- Balci, T.B., Prykhozhij, S.V., Teh, E.M., Da'as, S.I., McBride, E., Liwski, R., Chute, I.C., Leger, D., Lewis, S.M., Berman, J.N. (2014) A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. British journal of haematology. 167(1):48-61
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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