Gene
ndufs4
- ID
- ZDB-GENE-050522-421
- Name
- NADH:ubiquinone oxidoreductase subunit S4
- Symbol
- ndufs4 Nomenclature History
- Previous Names
-
- zgc:112289
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in electron transport chain. Predicted to localize to mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease and mitochondrial complex I deficiency. Is expressed in brain; myotome; and pharyngeal arch 3-7. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907533 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nuclear type mitochondrial complex I deficiency 1 | Alliance | Mitochondrial complex I deficiency, nuclear type 1 | 252010 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily | NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like |
|---|---|---|---|
|
UniProtKB:Q502E4
|
168 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndufs4-201
(1)
|
Ensembl | 629 nt |
Interactions and Pathways
No data available
Plasmids
No data available