Gene
ndufs4
- ID
- ZDB-GENE-050522-421
- Name
- NADH:ubiquinone oxidoreductase subunit S4
- Symbol
- ndufs4 Nomenclature History
- Previous Names
-
- zgc:112289
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in electron transport chain. Predicted to localize to mitochondrial respiratory chain complex I. Is expressed in brain; myotome; and pharyngeal arch 3-7. Human ortholog(s) of this gene implicated in Leigh disease and mitochondrial complex I deficiency. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907533 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nuclear type mitochondrial complex I deficiency 1 | Alliance | Mitochondrial complex I deficiency, nuclear type 1 | 252010 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily | NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like |
|---|---|---|---|
|
UniProtKB:Q502E4
|
168 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
ndufs4-201
(1)
|
Havana | 629 nt |
Interactions and Pathways
No data available
Plasmids
No data available