Gene
ephb2b
- ID
- ZDB-GENE-050522-415
- Name
- eph receptor B2b
- Symbol
- ephb2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in central nervous system projection neuron axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Knickmeyer et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001426 | Tyrosine-protein kinase, receptor class V, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001090 | Ephrin receptor ligand binding domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR027936 | Ephrin receptor, transmembrane domain |
| Domain | IPR034238 | Ephrin type-B receptor 2, ligand binding domain |
| Family | IPR016257 | Ephrin receptor type-A /type-B |
| Family | IPR050449 | Ephrin receptor tyrosine kinases |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin receptor tyrosine kinases | Ephrin type-B receptor 2, ligand binding domain | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase ephrin type A/B receptor-like | Tyrosine-protein kinase, receptor class V, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PUX4
|
937 | ||||||||||||||||||||
|
UniProtKB:A2CEJ3
|
989 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ephb2b-201
(1)
|
Ensembl | 8,285 nt | ||
| mRNA |
ephb2b-202
(1)
|
Ensembl | 3,233 nt | ||
| mRNA |
ephb2b-203
(1)
|
Ensembl | 5,458 nt |
Interactions and Pathways
No data available
Plasmids
No data available