Gene
endog
- ID
- ZDB-GENE-050522-402
- Name
- endonuclease G
- Symbol
- endog Nomenclature History
- Previous Names
-
- wu:fb79c08
- zgc:110020
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human ENDOG (endonuclease G).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11931 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018524 | DNA/RNA non-specific endonuclease, active site |
| Domain | IPR001604 | DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain |
| Domain | IPR020821 | ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain |
| Family | IPR040255 | Non-specific endonuclease |
| Homologous_superfamily | IPR044925 | His-Me finger superfamily |
| Homologous_superfamily | IPR044929 | DNA/RNA non-specific endonuclease superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA/RNA non-specific endonuclease, active site | DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain | DNA/RNA non-specific endonuclease superfamily | ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain | His-Me finger superfamily | Non-specific endonuclease |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q503Y0 | InterPro | 306 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-34G4 | ZFIN Curated Data | |
| Encodes | EST | fb79c08 | ||
| Encodes | cDNA | MGC:110020 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191433 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001024214 (1) | 1391 nt | ||
| Genomic | GenBank:CR382382 (1) | 403128 nt | ||
| Polypeptide | UniProtKB:Q503Y0 (1) | 306 aa |
- Gora, A.H., Rehman, S., Kiron, V., Dias, J., Fernandes, J.M.O., Olsvik, P.A., Siriyappagouder, P., Vatsos, I., Schmid-Staiger, U., Frick, K., Cardoso, M. (2022) Management of Hypercholesterolemia Through Dietary ß-glucans-Insights From a Zebrafish Model. Frontiers in nutrition. 8:797452
- Zhou, Z.J., Sun, L. (2016) Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Frontiers in cellular and infection microbiology. 6:76
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zou, J., Li, W.Q., Li, Q., Li, X.Q., Zhang, J.T., Liu, G.Q., Chen, J., Qiu, X.X., Tian, F.J., Wang, Z.Z., Zhu, N., Qin, Y.W., Shen, B., Liu, T.X., and Jing, Q. (2011) Two Functional MicroRNA-126s Repress a Novel Target Gene p21-Activated Kinase 1 to Regulate Vascular Integrity in Zebrafish. Circulation research. 108(2):201-209
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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