Gene
six6b
- ID
- ZDB-GENE-050522-308
- Name
- SIX homeobox 6b
- Symbol
- six6b Nomenclature History
- Previous Names
-
- si:dkey-225h23.3
- zgc:110344
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in camera-type eye development. Predicted to localize to nucleus and transcription regulator complex. Is expressed in hypothalamus. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Optic disc anomalies with retinal and/or macular dystrophy | 212550 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR031701 | Homeobox protein SIX1, N-terminal SD domain |
Domain Details Per Protein
Protein | Length | Homeobox protein SIX1, N-terminal SD domain |
---|---|---|
UniProtKB:Q5TYZ2
|
245 |
Interactions and Pathways
No data available
Plasmids
No data available