Gene

six6b

ID
ZDB-GENE-050522-308
Name
SIX homeobox 6b
Symbol
six6b Nomenclature History
Previous Names
  • si:dkey-225h23.3
  • zgc:110344
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in camera-type eye development and cell population proliferation. Predicted to localize to nucleus and transcription regulator complex. Is expressed in hypothalamus. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 4 from Armant et al., 2013
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With six6b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
optic disc anomalies with retinal and/or macular dystrophy Alliance Optic disc anomalies with retinal and/or macular dystrophy 212550
Associated With six6b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
Family IPR032947 Homeobox protein SIX6
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox domain Homeobox-like domain superfamily Homeobox protein SIX1, N-terminal SD domain Homeobox protein SIX6
UniProtKB:Q6DH09 162
UniProtKB:Q5TYZ2 245
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations