Gene

six6b

ID
ZDB-GENE-050522-308
Name
SIX homeobox 6b
Symbol
six6b Nomenclature History
Previous Names
  • si:dkey-225h23.3
  • zgc:110344
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in cell proliferation involved in compound eye morphogenesis. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Is expressed in hypothalamus. Orthologous to human SIX6 (SIX homeobox 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With six6b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Optic disc anomalies with retinal and/or macular dystrophy 212550
Associated With six6b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
Domain Details Per Protein
Protein Length Homeobox protein SIX1, N-terminal SD domain
UniProtKB:Q5TYZ2 245
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA six6b-201 (1) Havana 1615 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations